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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >Phospholipase (e.g. PLA) inhibitors >VARESPLADIB

VARESPLADIB

VARESPLADIB Structure
  • ₹11009.03 - ₹44339.2
  • Product name: VARESPLADIB
  • CAS: 172732-68-2
  • MF: C21H20N2O5
  • MW: 380.39
  • EINECS:1592732-453-0
  • MDL Number:MFCD00944812
  • Synonyms:LY-333013;Varespladib (LY315920);2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid;2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxyacetic acid;VARESPLADIB;LY315920(Varespladib);2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]Acetic Acid;[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1100
  • Product descriptionVarespladib ≥98% (HPLC)
  • Packaging5MG
  • Price₹11009.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1100
  • Product descriptionVarespladib ≥98% (HPLC)
  • Packaging25MG
  • Price₹44339.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1100 Varespladib ≥98% (HPLC) 5MG ₹11009.03 2022-06-14 Buy
Sigma-Aldrich(India) SML1100 Varespladib ≥98% (HPLC) 25MG ₹44339.2 2022-06-14 Buy

Properties

Melting point :230-234 °C
Boiling point :667.9±65.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
pka :3.12±0.40(Predicted)
color :white to beige

Safety Information

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Description

LY315920 is an inhibitor of human group IIA (hGIIA) secretory phospholipase A2 (sPLA2; IC50 = 9 nM). It also potently inhibits human GIIE and GX isoforms, as well as the corresponding mouse isoforms, but poorly inhibits other PLA2 enzymes. LY315920 inhibits sPLA2-induced release of thromboxane A2 from isolated guinea pig lung bronchoalveolar lavage cells (IC50 = 0.79 μM). Intravenous or oral administration of LY315920 to transgenic mice expressing human sPLA2 inhibits serum sPLA2 activity in a dose-related manner over four hours.

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