1''-BENZYL-3H-SPIRO[2-BENZOFURAN-1,4''-PIPERIDIN]-3-ONE synthesis

12synthesis methods

Product Name:1''-BENZYL-3H-SPIRO[2-BENZOFURAN-1,4''-PIPERIDIN]-3-ONE
CAS Number:37663-42-6
Molecular formula:C19H19NO2
Molecular Weight:293.36

93-98-1
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$15.00/5mg

3612-20-2 Synthesis

3612-20-2
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1''-BENZYL-3H-SPIRO[2-BENZOFURAN-1,4''-PIPERIDIN]-3-ONE

37663-42-6
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Yield:37663-42-6 88%

Reaction Conditions:

Stage #1: N-phenyl benzoyl amidewith n-butyllithium in tetrahydrofuran at -78 - 0;Inert atmosphere;
Stage #2: 1-phenylmethyl-4-piperidone in tetrahydrofuran at 0 - 20;Inert atmosphere;
Stage #3: with hydrogenchloride in tetrahydrofuran;water;

References:

Trapella, Claudio;Fischetti, Carmela;Pela', Michela;Lazzari, Ilaria;Guerrini, Remo;Calo', Girolamo;Rizzi, Anna;Camarda, Valeria;Lambert, David G.;McDonald, John;Regoli, Domenico;Salvadori, Severo [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 14,p. 5080 - 5095] Location in patent:experimental part

3612-20-2 Synthesis

3612-20-2
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$6.00/10g

610-97-9 Synthesis