ChemicalBook CAS DataBase List Chloropyramine

Chloropyramine synthesis

6synthesis methods

Product Name:Chloropyramine
CAS Number:59-32-5
Molecular formula:C16H20ClN3
Molecular Weight:289.8

Chloropyramine, N-(4-chlorobenzyl)-N′,N′-dimethyl-N-2-pyridylethylenediamine (16.1.9), is synthesized in a somewhat different manner, which is by reacting 2-brompyridine with N-(4-chlorobenzyl)-N′,N′-dimethylethylenediamine (16.1.8). N-(4-Chlorobenzyl)-N′,N′-dimethylethylenediamine (16.1.8), in turn, is synthesized by condensation of 4-chlorobenzaldehyde c N,N-dimethylethylenediamine with subsequent reduction of the imine group.

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: toluene; NaNH₂ / anschliessend mit <2-Chlor-aethyl>-dimethyl-amin
2: pyridine
3: pyridine; P₂S₅
4: Raney nickel; acetone

References:

Toldy et al. [Acta Chimica Academiae Scientiarum Hungaricae,1958,vol. 15,p. 265,269]

109-04-6 Synthesis