ChemicalBook CAS DataBase List INCB8761(PF-4136309)

INCB8761(PF-4136309) synthesis

6synthesis methods

Product Name:INCB8761(PF-4136309)
CAS Number:1341224-83-6
Molecular formula:C29H31F3N6O3
Molecular Weight:568.59

624-28-2 Synthesis

624-28-2
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1341224-83-6
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$25.00/1mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C

References:

Xue, Chu-Biao;Wang, Anlai;Han, Qi;Zhang, Yingxin;Cao, Ganfeng;Feng, Hao;Huang, Taisheng;Zheng, Changsheng;Xia, Michael;Zhang, Ke;Kong, Lingquan;Glenn, Joseph;Anand, Rajan;Meloni, David;Robinson;Shao, Lixin;Storace, Lou;Li, Mei;Hughes, Robert O.;Devraj, Rajesh;Morton, Philip A.;Rogier, D. Joseph;Covington, Maryanne;Scherle, Peggy;Diamond, Sharon;Emm, Tom;Yeleswaram, Swamy;Contel, Nancy;Vaddi, Kris;Newton, Robert;Hollis, Greg;Metcalf, Brian [ACS Medicinal Chemistry Letters,2011,vol. 2,# 12,p. 913 - 918]