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Isosorbide synthesis
- Product Name:Isosorbide
- CAS Number:652-67-5
- Molecular formula:C6H10O4
- Molecular Weight:146.14
![Sorbitol](/CAS/GIF/50-70-4.gif)
50-70-4
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$5.00/10g
![Isosorbide](/CAS/GIF/652-67-5.gif)
652-67-5
388 suppliers
$5.00/25g
Yield:652-67-5 96.1%
Reaction Conditions:
with sulfuric acid in water at 150; under 75.0075 Torr; for 3 h;Reagent/catalyst;
Steps:
1-4 Example 1 According to the Invention
1 kg of a sorbitol solution with a solids content of 70% (i.e. 700 g dry) sold by the Applicant under the name Neosorb 70/02 is introduced into a 1 liter Schott brand glass reactor, equipped with a jacket fed with an oil-circulation thermostatic bath, a stirring paddle, a thermometer, a distillation head combined with a condenser and a distillation receiver. The whole assembly is then connected to a vacuum pump equipped with a vacuum gauge. Stirring is switched on at 650 rpm. The sorbitol solution is then heated under vacuum (120° C.-100 mbar) so as to distil off the water present in the solution. After distillation of 279 g of water, 721 g of a sorbitol solution containing 97% solids are obtained. 7 g of concentrated sulfuric acid are added and the mixture obtained is then heated under vacuum (pressure of about 100 mbar) at 150° C. for 3 hours so as to perform the sorbitol dehydration reaction.The reaction crude is then cooled to 100° C. and then neutralized with 11.4 g of a 50% sodium hydroxide solution. 575 g of a neutralized isohexide composition containing 71.5%, i.e. 411 g, of isosorbide are obtained. The composition obtained is then introduced over 2 hours by means of a gear pump into a VDL 70-4 glass scraped-film evaporator with an evaporation surface area of 0.05 m2, the jacket of which is heated at 200° C. under a vacuum of 5 mbar. 395 g of distilled isosorbide are obtained, which corresponds to a distillation yield of 96.1%. The Gardner color of the isosorbide obtained after distillation is measured on the melted product in a cell with an optical path length of 1 cm, using a Lovibond PFXi-195/1 colorimeter. A color value of 2.1 Gardner is obtained.
References:
US2019/92782,2019,A1 Location in patent:Paragraph 0041-0049
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652-67-5
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652-67-5
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![Sorbitol](/CAS/GIF/50-70-4.gif)
50-70-4
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![Isosorbide](/CAS/GIF/652-67-5.gif)
652-67-5
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50-70-4
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![Isosorbide](/CAS/GIF/652-67-5.gif)
652-67-5
388 suppliers
$5.00/25g