ChemicalBook CAS DataBase List SINOVA SL-02580

SINOVA SL-02580 synthesis

9synthesis methods

Product Name:SINOVA SL-02580
CAS Number:357263-13-9
Molecular formula:C22H22N4O4
Molecular Weight:406.43

271-63-6
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$9.00/5g

357263-13-9
68 suppliers
$35.00/1mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1: AlCl₃ / CH₂Cl₂ / 8 h / 20 °C
2: 90.4 percent / K₂CO₃ / methanol; H₂O / 8 h
3: 81 percent / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; N,N-diisopropylethylamine / dimethylformamide / 8 h / 20 °C
4: 91 percent / mCPBA / acetone / 8 h
5: HNO₃; CF₃CO₂H / 8 h
6: methanol / 8 h / Heating
7: 5.7 g / PCl₃ / ethyl acetate / 8 h / 20 °C

References:

Wang, Tao;Zhang, Zhongxing;Wallace, Owen B.;Deshpande, Milind;Fang, Haiquan;Yang, Zheng;Zadjura, Lisa M.;Tweedie, Donald L.;Huang, Stella;Zhao, Fang;Ranadive, Sunanda;Robinson, Brett S.;Gong, Yi-Fei;Ricarrdi, Keith;Spicer, Timothy P.;Deminie, Carol;Rose, Ronald;Wang, Hwei-Gene Heidi;Blair, Wade S.;Shi, Pei-Yong;Lin, Pin-Fang;Colonno, Richard J.;Meanwell, Nicholas A. [Journal of Medicinal Chemistry,2003,vol. 46,# 20,p. 4236 - 4239]