Clevidipine butyrate
- CAS No.
- 167221-71-8
- Chemical Name:
- Clevidipine butyrate
- Synonyms
- Cleviprex;CS-136;H 324/38;Clevelox;evidipine;rac-Clevidipine;4-b-D-Xylopentaose;Clevidipine butyrate;CLEVELOX; CLEVIDIPINE;Cloweidipine butyrate
- CBNumber:
- CB01248667
- Molecular Formula:
- C21H23Cl2NO6
- Molecular Weight:
- 456.32
- MOL File:
- 167221-71-8.mol
- Modify Date:
- 2024/11/19 20:33:22
| Melting point | 128-130°C |
|---|---|
| Boiling point | 539.7±50.0 °C(Predicted) |
| Density | 1.289 |
| Flash point | 280℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Insoluble[in water] |
| Water Solubility | Insoluble in water |
| solubility | ≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic |
| form | powder to crystal |
| pka | 2.45±0.70(Predicted) |
| color | White to Light yellow |
| CAS DataBase Reference | 167221-71-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Clevidipine butyrate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2607 | Clevidipine Butyrate ≥98% (HPLC) | 167221-71-8 | 10MG | ₹8042.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2607 | Clevidipine Butyrate ≥98% (HPLC) | 167221-71-8 | 50MG | ₹32464.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C3503 | Clevidipine | 167221-71-8 | 250MG | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3503 | Clevidipine | 167221-71-8 | 1G | ₹9200 | 2022-05-26 | Buy |
Clevidipine butyrate Chemical Properties,Uses,Production
Description
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine
(DHP) class of CCB. It is indicated as an intravenous treatment for the
acute management of hypertension when oral therapy is not feasible or
not desirable. Clevidipine is the second intravenous CCB to be marketed
behind nicardipine for this indication. Both agents are primarily used
for urgent treatment of hypertension in cardiac surgical setting, intensive
care units, and emergency departments. Other intravenous agents
currently on the market for this indication include sodium nitroprusside,
nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect
on the myocardial contractility and venous capacitance. It has a
rapid onset and offset of action and a very short plasma half-life, which
allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
Chemical Properties
White to Off-White Solid
Uses
Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。
Side effects
Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.
Clevidipine butyrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| MSN LABORATORIES PRIVATE LTD | +91 40 30438600 | New Delhi, India | 230 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6088 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | China | 8806 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2472 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21634 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32956 | 60 | Inquiry |
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