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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Structure
CAS No.
161797-99-5
Chemical Name:
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Synonyms
ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester
CBNumber:
CB02128586
Molecular Formula:
C13H13NO3S
Molecular Weight:
263.31
MOL File:
161797-99-5.mol
MSDS File:
SDS
Modify Date:
2024/8/21 22:41:43
Request For Quotation

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Properties

Melting point 180 ºC
Boiling point 426.8±55.0 °C(Predicted)
Density 1.274
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
pka 8.56±0.15(Predicted)
color Off-White
InChI InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
InChIKey LOCYSKNNFCGDTR-UHFFFAOYSA-N
SMILES S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
CAS DataBase Reference 161797-99-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
NFPA 704
1
2 0

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ALFA India ALF-H52223-06 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 161797-99-5 5g ₹49242 2022-05-26 Buy
ALFA India ALF-H52223-03 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 161797-99-5 1g ₹12345 2022-05-26 Buy
Product number Packaging Price Buy
ALF-H52223-06 5g ₹49242 Buy
ALF-H52223-03 1g ₹12345 Buy

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

4-Cyanophenol 4-Hydroxythiobenzamide

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

Global( 384)Suppliers
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VASUDHA PHARMA CHEM LIMITED +91-91-4044763666 +91-9396659284 Telangana, India 101 58 Inquiry
Bhausa Life Sciences +91-8154986830 +91-8154986830 Gujarat, India 201 58 Inquiry
SYNARTIS PHARMA PVT LTD +919949688280 Hyderabad, India 92 58 Inquiry
Everest Organics Limited +91-4040028838 +91-9440409996 Hyderabad, India 61 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Prodev Pharma Pvt Ltd +91-9963029529 +91-9043422844 Telangana, India 102 58 Inquiry
Clickchem Research LLP +91-8140031133 +91-8140031133 Gujarat, India 411 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
Supplier Advantage
VASUDHA PHARMA CHEM LIMITED 58
Bhausa Life Sciences 58
SYNARTIS PHARMA PVT LTD 58
Everest Organics Limited 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Ralington Pharma 58
Prodev Pharma Pvt Ltd 58
Clickchem Research LLP 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58

161797-99-5(Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate)Related Search:

ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Descyano Impurity isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID
FeBuxostat Impurity 18 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Impurity 8 Methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate 4-HYDROXYTHIOBENZAMIDE
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 4-Methylthiazole
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ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester Intermediates of Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Descyano Hydroxy Ethyl Ester 3-thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2- Febuxostat Desaldehyde Impurity CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl Febuxostat intermediates，Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97% ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2- Febuxostat-8 ethyl 2-(4-hydroxyphenyl) Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G) ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate(G) Ethyl 2-(4-hydroxyphenyl)-4- ethylthiazole-5-carboxylate Intermediate 2 of non brucite Ethyl 2-(4-+B1:C32Hydroxyphenyl)-4-Methyl-5- Thiazolecarboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate（F2） Febuxostat Impurity A-1 161797-99-5 161798-99-5 Febuxostat Intermediates Febuxostat intermediate