ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS No.: 161797-99-5

Chemical Name:: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Synonyms: ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester

CBNumber:: CB02128586

Molecular Formula:: C13H13NO3S

Molecular Weight:: 263.31

MOL File:: 161797-99-5.mol

MSDS File:: SDS

Modify Date:: 2024/7/29 15:17:36

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Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Properties

Melting point	180 ºC
Boiling point	426.8±55.0 °C(Predicted)
Density	1.274
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Very Slightly)
form	Solid
pka	8.56±0.15(Predicted)
color	Off-White
InChI	InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
InChIKey	LOCYSKNNFCGDTR-UHFFFAOYSA-N
SMILES	S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
CAS DataBase Reference	161797-99-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

NFPA 704

	1
2		0

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ALFA India	ALF-H52223-06	Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%	161797-99-5	5g	₹49242	2022-05-26	Buy
ALFA India	ALF-H52223-03	Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%	161797-99-5	1g	₹12345	2022-05-26	Buy

Product number	Packaging	Price	Buy
ALF-H52223-06	5g	₹49242	Buy
ALF-H52223-03	1g	₹12345	Buy

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate.

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

4-Cyanophenol 4-Hydroxythiobenzamide

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

Global( 371)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
VASUDHA PHARMA CHEM LIMITED	+91-91-4044763666 +91-9396659284	Telangana, India	102	58	Inquiry
Bhausa Life Sciences	+91-8154986830 +91-8154986830	Gujarat, India	201	58	Inquiry
SYNARTIS PHARMA PVT LTD	+919949688280	Hyderabad, India	92	58	Inquiry
Everest Organics Limited	+91-4040028838 +91-9440409996	Hyderabad, India	61	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Orgamine Chemicals(I) Pvt Ltd	+91-9820080281 +91-9820080281	Maharashtra, India	451	58	Inquiry
Prodev Pharma Pvt Ltd	+91-9963029529 +91-9043422844	Telangana, India	102	58	Inquiry
Clickchem Research LLP	+91-8140031133 +91-8140031133	Gujarat, India	411	58	Inquiry
Anant Pharmaceuticals Pvt. ltd	+91 8550986868	Maharashtra, India	736	58	Inquiry

Supplier	Advantage
VASUDHA PHARMA CHEM LIMITED	58
Bhausa Life Sciences	58
SYNARTIS PHARMA PVT LTD	58
Everest Organics Limited	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Ralington Pharma	58
Orgamine Chemicals(I) Pvt Ltd	58
Prodev Pharma Pvt Ltd	58
Clickchem Research LLP	58
Anant Pharmaceuticals Pvt. ltd	58

161797-99-5(Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate)Related Search:

ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Descyano Impurity isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID

FeBuxostat Impurity 18 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Impurity 8 Methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate 4-HYDROXYTHIOBENZAMIDE

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 4-Methylthiazole

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ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester Intermediates of Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Descyano Hydroxy Ethyl Ester 3-thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2- Febuxostat Desaldehyde Impurity CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl Febuxostat intermediates，Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97% ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2- Febuxostat-8 ethyl 2-(4-hydroxyphenyl) Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G) ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate(G) Ethyl 2-(4-hydroxyphenyl)-4- ethylthiazole-5-carboxylate Intermediate 2 of non brucite Febuxostat Impurity A-1 Ethyl 2-(4-+B1:C32Hydroxyphenyl)-4-Methyl-5- Thiazolecarboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate（F2） 161797-99-5 161798-99-5 Febuxostat Intermediates Febuxostat intermediate