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ChemicalBook > Product Catalogue >Organic Chemistry >Carboxylic acids and derivatives >Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Structure
  • ₹12345 - ₹49242
  • Product name: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
  • CAS: 161797-99-5
  • MF: C13H13NO3S
  • MW: 263.31
  • EINECS:605-268-8
  • MDL Number:MFCD03700424
  • Synonyms:ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester;5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester;Intermediates of Febuxostat;Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate;Febuxostat Descyano Hydroxy Ethyl Ester
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • ALFA India

Package

  • 1g
  • 5g
  • ManufacturerALFA India
  • Product numberALF-H52223-03
  • Product descriptionEthyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
  • Packaging1g
  • Price₹12345
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-H52223-06
  • Product descriptionEthyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
  • Packaging5g
  • Price₹49242
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-H52223-03 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 1g ₹12345 2022-05-26 Buy
ALFA India ALF-H52223-06 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 5g ₹49242 2022-05-26 Buy

Properties

Melting point :180 ºC
Boiling point :426.8±55.0 °C(Predicted)
Density :1.274
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Very Slightly)
form :Solid
pka :8.56±0.15(Predicted)
color :Off-White
InChI :InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
InChIKey :LOCYSKNNFCGDTR-UHFFFAOYSA-N
SMILES :S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
CAS DataBase Reference :161797-99-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

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ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 4-HYDROXYTHIOBENZAMIDE Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate Febuxostat Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 4-Methylthiazole

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Suppliers and manufacturers

VASUDHA PHARMA CHEM LIMITED Bhausa Life Sciences SYNARTIS PHARMA PVT LTD Everest Organics Limited Rivashaa Agrotech Biopharma Pvt. Ltd. Ralington Pharma Alliance Pharma Orgamine Chemicals(I) Pvt Ltd Prodev Pharma Pvt Ltd Clickchem Research LLP