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(S)-MEPHENYTOIN

CAS No.: 50-12-4

Chemical Name:: (S)-MEPHENYTOIN

Synonyms: Epilan;Epiazin;Methoin;Metydan;Sacerno;Insulton;Fenantoin;Mesantoin;Mesontoin;NSC-34652

CBNumber:: CB0225135

Molecular Formula:: C12H14N2O2

Molecular Weight:: 218.25

MOL File:: 50-12-4.mol

MSDS File:: SDS

Modify Date:: 2023/6/27 14:18:49

Request For Quotation

(S)-MEPHENYTOIN Properties

Melting point	135-138 °C
Boiling point	358.94°C (rough estimate)
Density	1.154±0.06 g/cm3 (20 ºC 760 Torr)
refractive index	1.6660 (estimate)
storage temp.	2-8°C
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	solid
pka	pKa 8.1 (Uncertain)
color	off-white
CAS DataBase Reference	50-12-4(CAS DataBase Reference)
EPA Substance Registry System	Mephenytoin (50-12-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	2
HS Code	2933210000
Toxicity	LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan)

(S)-MEPHENYTOIN Chemical Properties,Uses,Production

Description

Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.

Uses

Anticonvulsant.

Biological Activity

CYP2C19 substrate. Anticonvulsant.

Side effects

Side effects, including rash, fever, and fatal blood dyscrasia, prevent the use as an anticonvulsant drug of first choice.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.

(S)-MEPHENYTOIN Preparation Products And Raw materials

Raw materials

Cyanide, Quant Test Strips Dilute hydrochloric acid Propiophenone POTASSIUM CYANIDE Ammonium carbonate

Sodium bisulfite Sodium MEPHOBARBITAL 1-(1-cyano-1-phenylpropyl)-3-methylurea 2,4-Imidazolidinedione, 5-ethyl-5-phenyl-, (+-)-

Methylamine Methylurea Iodomethane N,N-Dimethylformamide dimethyl acetal

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Preparation Products

(S)-MEPHENYTOIN Suppliers

Global( 102)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10991	58	Inquiry
Shandong Mopai Biotechnology Co., Ltd	13070690626 13053322091	China	11056	58	Inquiry
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	18502726233; 18502726233	China	9808	58	Inquiry
BOC Sciences		USA	0	65	Inquiry
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	China	8000	58	Inquiry
Shanghai Maclean Biochemical Technology Co., LTD	021-50706066 15221275939	China	29802	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shandong Mopai Biotechnology Co., Ltd	58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	58
BOC Sciences	65
Hefei Mokai Pharmaceutical Technology Co., Ltd	58
Shanghai Maclean Biochemical Technology Co., LTD	58

50-12-4((S)-MEPHENYTOIN)Related Search:

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(4-ETHYL-2,5-DIOXO-4-PHENYLIMIDAZOLIDIN-1-YL)ACETIC ACID (2,5-DIOXO-3',4'-DIHYDRO-1H,2'H-SPIRO[IMIDAZOLIDINE-4,1'-NAPHTHALEN]-1-YL)ACETIC ACID (2,5-DIOXO-2',3'-DIHYDRO-1H-SPIRO[IMIDAZOLIDINE-4,1'-INDEN]-1-YL)ACETIC ACID

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(S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE (S)-(+)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN (S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN (S)-(+)-MEPHENYTOIN (+/-)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE (+/-)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN (+/-)-MEPHENYTOIN MEPHENYTOIN Epiazin Epilan Fenantoin Gerot-epilan Hydantoin, 5-ethyl-3-methyl-5-phenyl- Insulton mephenetoinum Mephentoin Mesantoin Mesdontoin Mesontoin Methoin Methyl hydantoin Methylphenetoin Metydan NSC-34652 Phenantoin Phenylethylmethylhydantoin Sacerno Sedantional Sedantoin Sedantoinal Triantoin 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl- 3-Ethylnirvanol 3-Methyl-5,5-ethylphenylhydantoin 3-Methyl-5,5-phenylethylhydantoin 3-Methyl-5-ethyl-5-phenylhydantoin 5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione 5-ethyl-3-methyl-5-phenyl-4-imidazolidinedione 5-ethyl-3-methyl-5-phenyl-hydantoi 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione 5-Ethyl-5-fenyl-3-methylhydantoin (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (±)-5-Ethyl-3-methyl-5-phenylhydantoin DL-Mephenytoin (5R)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione (5R)-5-Ethyl-3-methyl-5-phenylhydantoin (5R)-5α-Ethyl-3-methyl-5-phenylhydantoin 5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione 5-Ethyl-3-methyl-5-phenethylhydantoin 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione Mephenytoin (250 mg) Mephenytoin-d3 MEPHENYTOIN; METHOIN; MESANTOIN; PHENANTOIN; METHYLPHENETOIN; INSULTON. (S)-MEPHENYTOIN USP/EP/BP Mephenitoin 50-12-4 1950-12-4