Vemakalant

Vemakalant Structure
CAS No.
794466-70-9
Chemical Name:
Vemakalant
Synonyms
CS-419;Vemakalant;Vernakalant;Vemakalant USP/EP/BP;Vernakalant (RSD-1235);VERNAKALANT;RSD1235;RSD 1235;RSD-1235;Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer);(3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol;(3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
CBNumber:
CB02498847
Molecular Formula:
C20H31NO4
Molecular Weight:
349.46
MOL File:
794466-70-9.mol
MSDS File:
SDS
Modify Date:
2023/5/21 10:59:17

Vemakalant Properties

Boiling point 479.0±45.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO
form Powder
pka 14.79±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Vemakalant Chemical Properties,Uses,Production

Description

Vernakalant is a potassium channel blocker that was approved in Europe in 2010 for treatment of atrial fibrillation (AF), a condition of cardiac arrhythmia in which the atria of the heart beat irregularly due to changes in cardiac ion channel function and distribution. Vernakalant has activity for cardiac Na+ and K+ channels and also for the atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized in animal models to assess efficacy, atrial selectivity, and reduction in side effects.

Originator

Cardiome Pharma Corp. (Canada)

brand name

Brinavess

Vemakalant Preparation Products And Raw materials

Raw materials

Preparation Products

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Vemakalant Vernakalant Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer) VERNAKALANT;RSD1235;RSD 1235;RSD-1235 CS-419 (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol (3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol 3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)- Vemakalant USP/EP/BP Vernakalant (RSD-1235) 794466-70-9