IPA-3
- CAS No.
- 42521-82-4
- Chemical Name:
- IPA-3
- Synonyms
- IPA 3;IPA 3;IPA3;1'-Dithiodi-2-naphthtol;1,1'-Dithiodi-2-naphthtol;2-Naphthalenol, 1,1'-dithiobis-;1,1′-Disulfanediyldinaphthalen-2-ol;Bis(2-hydroxy-1-naphthyl) disulfide;1,1'-Dithiodi-2-naphthtol USP/EP/BP;1,1'-Disulfanediylbis(naphthalen-2-ol);1,1'-Disulfanediylbis(naphthalen-2-ol)
- CBNumber:
- CB02518903
- Molecular Formula:
- C20H14O2S2
- Molecular Weight:
- 350.45
- MOL File:
- 42521-82-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 172℃ |
|---|---|
| Boiling point | 543.7±35.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| pka | 7.52±0.50(Predicted) |
| form | Yellow solid |
| color | off-white to yellow |
| Water Solubility | Soluble in DMSO or ethanol. Insoluble in water. |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 42521-82-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H410 | |||||||||
| Precautionary statements | P273-P280-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 41-50/53 | |||||||||
| Safety Statements | 26-39-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| NFPA 704 |
|
IPA-3 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I2285 | IPA-3 ≥95% (HPLC), powder | 42521-82-4 | 5MG | ₹10695.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2285 | IPA-3 ≥95% (HPLC), powder | 42521-82-4 | 25MG | ₹42661.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 506106 | p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm | 42521-82-4 | 5MG | ₹8310 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 506106 | p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm | 42521-82-4 | 25MG | ₹27450.01 | 2022-06-14 | Buy |
IPA-3 Chemical Properties,Uses,Production
Uses
p21-activated kinase 1 (PAK1) is a member of a family non-receptor serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAK1 results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAK1 expression and activity is upregulated in several human cancers and is a potential therapeutic target for cancer intervention. IPA-3 is a cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.[Cayman Chemical]
Definition
ChEBI: An organic disulfide obtained by oxidative dimerisation of 1-sulfanylnaphthalen-2-ol.
Biochem/physiol Actions
IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.
IPA-3 Preparation Products And Raw materials
Raw materials
Preparation Products
IPA-3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Haoyang Biological Technology Co., Ltd. | 021-54046790 15121098156 | CHINA | 2905 | 58 | Inquiry |
| Shanghai Yaoyun Biological Technology Co., Ltd. | 400-002-6926 400-002-6926 | CHINA | 6852 | 58 | Inquiry |
| Beijing Baiao Innovation Technology Co., Ltd. | 010-5718533 13366620421 | CHINA | 6005 | 58 | Inquiry |
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