PTC-209 (PTC209
- CAS No.
- 315704-66-6
- Chemical Name:
- PTC-209 (PTC209
- Synonyms
- PTC-209;CS-1315;PTC 209 NEW;PTC-209, >=98%;PTC-209 (PTC209;PTC-209 free base;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine;N-(2,6-dibroMo-4-Methoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyriMidin-3-yl)thiazol-2-aMine;2-THIAZOLAMINE, N-(2,6-DIBROMO-4-METHOXYPHENYL)-4-(2-METHYLIMIDAZO[1,2-A]PYRIMIDIN-3-YL)-;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine PTC-209
- CBNumber:
- CB02682264
- Molecular Formula:
- C17H13Br2N5OS
- Molecular Weight:
- 495.19
- MOL File:
- 315704-66-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Density | 1.86±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 3.77±0.30(Predicted) |
| form | powder |
| color | white to brown |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 315704-66-6 |
PTC-209 (PTC209 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1143 | PTC-209 ≥98% (HPLC) | 315704-66-6 | 5MG | ₹11009.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1143 | PTC-209 ≥98% (HPLC) | 315704-66-6 | 25MG | ₹44339.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.30154 | BMI-1 Expression Inhibitor, PTC-209 - CAS 315704-66-6 - Calbiochem A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription. | 315704-66-6 | 10MG | ₹22390 | 2022-06-14 | Buy |
PTC-209 (PTC209 Chemical Properties,Uses,Production
Uses
Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.[Cayman Chemical]
Biochem/physiol Actions
PTC-209 inhibits the expression of the oncogene BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog), which encodes a polycomb group RING finger protein involved in cell cycle. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs) The compound inhibits tumor growth, and reduces the levels of CICs present in colon cancer tumor xenografts in mice.
PTC-209 (PTC209 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Golden Pharma Co., Limited | +undefined18958062155 | China | 5905 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
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