PTC-209 (PTC209
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- ₹11009.03 - ₹44339.2
- Product name: PTC-209 (PTC209
- CAS: 315704-66-6
- MF: C17H13Br2N5OS
- MW: 495.19
- EINECS:808-910-7
- MDL Number:MFCD02110649
- Synonyms:PTC-209 (PTC209;PTC-209;N-(2,6-dibroMo-4-Methoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyriMidin-3-yl)thiazol-2-aMine;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine PTC-209;PTC-209, >=98%;2-THIAZOLAMINE, N-(2,6-DIBROMO-4-METHOXYPHENYL)-4-(2-METHYLIMIDAZO[1,2-A]PYRIMIDIN-3-YL)-;PTC-209 free base
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1143
- Product descriptionPTC-209 ≥98% (HPLC)
- Packaging25MG
- Price₹44339.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.30154
- Product descriptionBMI-1 Expression Inhibitor, PTC-209 - CAS 315704-66-6 - Calbiochem A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
- Packaging10MG
- Price₹22390
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1143
- Product descriptionPTC-209 ≥98% (HPLC)
- Packaging5MG
- Price₹11009.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1143 | PTC-209 ≥98% (HPLC) | 25MG | ₹44339.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.30154 | BMI-1 Expression Inhibitor, PTC-209 - CAS 315704-66-6 - Calbiochem A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription. | 10MG | ₹22390 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1143 | PTC-209 ≥98% (HPLC) | 5MG | ₹11009.03 | 2022-06-14 | Buy |
Properties
Density :1.86±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :3.77±0.30(Predicted)
form :powder
color :white to brown
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :315704-66-6
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :3.77±0.30(Predicted)
form :powder
color :white to brown
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :315704-66-6
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.More related product prices
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