DODMA
- CAS No.
- 104162-47-2
- Chemical Name:
- DODMA
- Synonyms
- 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC);N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine
- CBNumber:
- CB02755573
- Molecular Formula:
- C41H81NO2
- Molecular Weight:
- 620.09
- MOL File:
- 104162-47-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| Boiling point | 649.7±55.0 °C(Predicted) |
|---|---|
| Density | 0.869±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in Ethanol, DMSO, DMF |
| pka | 8.65±0.28(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| BRN | 10139013 |
| InChIKey | GLGLUQVVDHRLQK-WRBBJXAJSA-N |
| SMILES | C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary statements | P201-P260-P264-P280-P304+P340+P311-P403+P233 |
| WGK Germany | 3 |
DODMA price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 53467 | 2,3-Dioleyloxy-1-(dimethylamino)propane ≥98.0% (TLC) | 104162-47-2 | 100MG | ₹11073.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 53467 | 2,3-Dioleyloxy-1-(dimethylamino)propane ≥98.0% (TLC) | 104162-47-2 | 500MG | ₹43776.3 | 2022-06-14 | Buy |
DODMA Chemical Properties,Uses,Production
Description
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.
Chemical Properties
DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.
Uses
DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.
Application
DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).
Biochem/physiol Actions
DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.
DODMA Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | China | 183 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7353 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9322 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 | China | 1134 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | China | 42057 | 58 | Inquiry |
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