BI 1744 hydrochloride
- CAS No.
- 869477-96-3
- Chemical Name:
- BI 1744 hydrochloride
- Synonyms
- BI-1744 HCl;Olodaterol HCl;BI 1744 hydrochloride;BI-1744;BI 1744;BI1744;Olodaterol(BI-1744) HCl;Olodaterol hydrochloride;BI 1744 hydrochloride USP/EP/BP;Olodaterol(BI-1744) hydrochloride;Odaterol hydrochloride impurity reference substance;6-hydroxy-8-[(1R)-1-hydroxy-2-[[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino]ethyl]-4H-1,4-benzoxazin-3-one
- CBNumber:
- CB03052079
- Molecular Formula:
- C21H27ClN2O5
- Molecular Weight:
- 422.90248
- MOL File:
- 869477-96-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/28 13:39:29
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H361-H302-H372 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501 |
BI 1744 hydrochloride Chemical Properties,Uses,Production
Description
Olodaterol hydrochloride was approved for long-term, oncedaily maintenance treatment of chronic obstructive pulmonary disease (COPD) in 2013 in the following countries: Canada, Russia, United Kingdom, Denmark, and Iceland. The drug has been recommended by a federal advisory panel for approval by the FDA. Developed and marketed by Boehringer Ingelheim, olodaterol is a long-acting b2-adrenergic receptor agonist with high selectivity over the b1- and b3-receptors (219- and 1622-fold, respectively). Upon binding to and activating the b2-adrenergic receptor in the airway, olodaterol stimulates adenyl cyclase to synthesize cAMP, leading to the relaxation of smooth muscle cells in the airway. Administered by inhalation using the Respimat® Soft Mist inhaler, it delivers significant bronchodilator effects within five minutes of the first dose and provides sustained improvement in forced expiratory volume (FEV1) for over 24 h.
Uses
Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
Definition
ChEBI: A hydrochloride obtained by combining olodaterol with one equivalent of hydrochloric acid. Used for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
BI 1744 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20366 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26415 | 58 | Inquiry |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | China | 19994 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Pharma Affiliates | 58 |
| Henan Fengda Chemical Co., Ltd | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| BOC Sciences | 58 |
| Dideu Industries Group Limited | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |