GSK872
- CAS No.
- 1346546-69-7
- Chemical Name:
- GSK872
- Synonyms
- GSK872;CS-2489;GSK2399872A;GSK'872 (GSK2399872A);GSK-872;GSK 872;GSK872;GSK' 872 (GSK2399872A);GSK'872;GSK872;GSK2399872A;N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine;N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine;N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
- CBNumber:
- CB03165850
- Molecular Formula:
- C19H17N3O2S2
- Molecular Weight:
- 383.49
- MOL File:
- 1346546-69-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 625.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.395±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| pka | 5.53±0.49(Predicted) |
| form | solid |
| color | Off-White or pale yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
GSK872 Chemical Properties,Uses,Production
Uses
GSK''872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).
GSK872 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 69)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | China | 9929 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9707 | 58 | Inquiry |
1346546-69-7(GSK872)Related Search:
GSK872
N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine
N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine HCl salt
N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine HCL SALT // GSK-872 HCL
4-Quinolinamine, N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-
GSK'872 (GSK2399872A)
GSK'872;GSK872;GSK2399872A
GSK2399872A
GSK-872;GSK 872;GSK872
CS-2489
N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine
translocation,GSK-872,neurological,HMGB1,Receptor-interacting protein kinases,brain,GSK 872,cytoplasmic,deficits,Inhibitor,edema,inhibit,RIPK,RIP kinase
GSK' 872 (GSK2399872A)
1346546-69-7