Phenelzine
- CAS No.
- 51-71-8
- Chemical Name:
- Phenelzine
- Synonyms
- nadil;Nardil;W-1544;w1544-a;W 1544-A;Fenelzyne;Fenelzyna;Stinerval;Phenalzine;PHENELZINE
- CBNumber:
- CB0434063
- Molecular Formula:
- C8H12N2
- Molecular Weight:
- 136.19
- MOL File:
- 51-71-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/28 13:39:29
| Melting point | 25°C |
|---|---|
| Boiling point | bp0.1 74° |
| Density | 1.0348 (rough estimate) |
| refractive index | nD20 1.5494 |
| pka | 8.01±0.70(Predicted) |
| CAS DataBase Reference | 51-71-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydrazine, (2-phenylethyl)-(51-71-8) |
| EPA Substance Registry System | Phenelzine (51-71-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P501-P202-P201-P280-P308+P313-P405 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| Toxicity | LD50 oral in mouse: 130mg/kg |
Phenelzine Chemical Properties,Uses,Production
Description
Monoamine oxidase inhibitors (MAOIs) were the first antidepressant drugs introduced during the 1950s. Associated with many side effects and, in particular, drug–drug and drug–food interactions, their use declined with the subsequent introduction of the tricyclic antidepressants and specific serotonin reuptake inhibitors as first-line treatments for depression.
Uses
Phenelzine is a MAO inhibitor which is used for treating patients with depressive characteristics such as “atypical,” “nonendogenous,” or “neurotic” conditions in which a combination of anxiety, depression, or phobia are observed. Phenelzine is not a drug of first choice, and it is used in depressions that do not respond to other medicinal drugs.
Mechanism of action
Phenelzine is a hydrazine MAOI. Its mechanism of action is the prolonged, nonselective, irreversible inhibition of MAO. Phenelzine has been used with some success in the management of bulimia nervosa. The MAOIs, however, are potentially dangerous in patients with binge eating and purging behaviors, and the American Psychiatric Association states that MAOIs should be used with caution in the management of bulimia nervosa.
Safety Profile
Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: ataxia, somnolence. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antidepressant. When heated to decomposition it emits toxic fumes of NOx.
Environmental Fate
MAOIs are available orally. Accidental or intentional ingestion are the most common routes of exposure.
Phenelzine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Kings Pharma | 08048372388Ext 253 | Mumbai, India | 1 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
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