S-(-)-Carbidopa
![S-(-)-Carbidopa Structure](CAS/GIF/28860-95-9.gif)
- CAS No.
- 28860-95-9
- Chemical Name:
- S-(-)-Carbidopa
- Synonyms
- S(-)-CARBIDOPA;mk486;KINSON;L-3-(3,4;Carbidopa-d3;(S)-CARBIDOPA;CARBIDOPA EDMF;n-aminomethyldopa;CARBIDOPAANHYDROUS;CarbidopaUsp28/Ep5
- CBNumber:
- CB5738078
- Molecular Formula:
- C10H14N2O4
- Molecular Weight:
- 226.23
- MOL File:
- 28860-95-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
Melting point | 203-205° (dec); mp 208° |
---|---|
alpha | D -17.3° (methanol) |
Boiling point | 367.84°C (rough estimate) |
Density | 1.2616 (rough estimate) |
refractive index | 1.5000 (estimate) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | powder |
pka | 3.40±0.14(Predicted) |
color | White to Off-White |
Stability | Unstable in Solution |
CAS DataBase Reference | 28860-95-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
RTECS | MW5298000 |
S-(-)-Carbidopa price More Price(2)
S-(-)-Carbidopa Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
in combinaison with levodopa as antiparkinsonian;inhibits aromatic-L-amino-acid decarboxylase (DOPA Decarboxylase or DDC)
Definition
ChEBI: 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversi n of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
General Description
Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.
Biological Activity
Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
S-(-)-Carbidopa Preparation Products And Raw materials
Raw materials
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