Carbidopa Monohydrate
- CAS No.
- 38821-49-7
- Chemical Name:
- Carbidopa Monohydrate
- Synonyms
- lodosyn;CARBIDOPA;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;CARBIDOPA HYDRATE;Carbidopa (400 mg);Carbidopa(CEP/FDA);Carbidopa Capsules;CARBIDOPA 1-HYDRATE
- CBNumber:
- CB7445183
- Molecular Formula:
- C10H16N2O5
- Molecular Weight:
- 244.25
- MOL File:
- 38821-49-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:16
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
|---|---|
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids. |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 38821-49-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MW5300000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2928002500 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974. | |||||||||
| NFPA 704 |
|
Carbidopa Monohydrate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1655 | Carbidopa Pharmaceutical Secondary Standard; Certified Reference Material | 38821-49-7 | 1G | ₹9926.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2450 | Carbidopa Monohydrate | 38821-49-7 | 100MG | ₹5500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2450 | Carbidopa Monohydrate | 38821-49-7 | 1G | ₹23000 | 2022-05-26 | Buy |
Carbidopa Monohydrate Chemical Properties,Uses,Production
Chemical Properties
white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.
Uses
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
Definition
ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).
General Description
Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pKa＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.
Carbidopa Monohydrate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| HETERO DRUGS LTD | +91 40 23704923 / 24 / 25 | New Delhi, India | 98 | 58 | Inquiry |
| Smruthi Organics Limited | 08069023792Ext 824 | Maharashtra, India | 17 | 58 | Inquiry |
| Glochem Industries Limited | 08069023898Ext 576 | Hyderabad, India | 9 | 58 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2006 | 58 | Inquiry |
| Mantena Laboratories Limited | +91 40 23741657 | Andhra Pradesh, India | 2 | 58 | Inquiry |
| Mesha Pharma Private Limited | 08048372569Ext 806 | Mumbai, India | 133 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Esschem (Private) Limited | 09833911146 | Mumbai, India | 39 | 58 | Inquiry |
| Synthink Research Chemicals | 09158051123 | Pune, India | 398 | 58 | Inquiry |
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