Parthenolide
- CAS No.
- 20554-84-1
- Chemical Name:
- Parthenolide
- Synonyms
- PTL;Nsc157035;Aids007764;Parthelide;Aids-007764;Parthenolide;PartheNAlide;Parthenolides;parthenolider;Parthenolide>
- CBNumber:
- CB0446848
- Molecular Formula:
- C15H20O3
- Molecular Weight:
- 248.32
- MOL File:
- 20554-84-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/4 15:29:52
| Melting point | 115-116 °C (lit.) |
|---|---|
| alpha | D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2) |
| Boiling point | 394.1±42.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml) |
| form | White solid |
| color | White |
| Merck | 14,7048 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
| InChIKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| SMILES | O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10| |
| LogP | 2.424 (est) |
| CAS DataBase Reference | 20554-84-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280-P302+P352 |
| Hazard Codes | Xi,C,F |
| Risk Statements | 11-34 |
| Safety Statements | 22-24/25-45-36/37/39-26-16 |
| WGK Germany | 3 |
| RTECS | LY4220000 |
| HS Code | 29322090 |
Parthenolide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P0667 | Parthenolide ≥98% (HPLC) | 20554-84-1 | 5MG | ₹5466.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0667 | Parthenolide ≥98% (HPLC) | 20554-84-1 | 25MG | ₹21195.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 512732 | Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. | 20554-84-1 | 50MG | ₹11880.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1982 | Parthenolide | 20554-84-1 | 25MG | ₹3900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1982 | Parthenolide | 20554-84-1 | 100MG | ₹10200 | 2022-05-26 | Buy |
Parthenolide Chemical Properties,Uses,Production
Description
Parthenolide is an allergen in feverfew (Tanacetum parthenarium).
Chemical Properties
White solid
Uses
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
Definition
ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .
Contact allergens
Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).
Parthenolide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Herbo Nutra | +91-8048966502 | Delhi, India | 27 | 58 | Inquiry |
| Vital Herbs | 08046067358 | Delhi, India | 36 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Phytocompounds | 91-80-40209999 | Karnataka, India | 35 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12459 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
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