Parthenolide
Parthenolide
- CAS:
- 20554-84-1
- MF:
- C15H20O3
- MW:
- 248.32
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Properties
- Melting point:
- 115-116 °C (lit.)
- alpha
- D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
- Boiling point:
- 394.1±42.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
- form
- White solid
- color
- White
- Merck
- 14,7048
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
- InChIKey
- KTEXNACQROZXEV-PVLRGYAZSA-N
- SMILES
- O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|
- LogP
- 2.424 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H317
- Precautionary statements
- P280-P302+P352
- Hazard Codes
- Xi,C,F
- Risk Statements
- 11-34
- Safety Statements
- 22-24/25-45-36/37/39-26-16
- WGK Germany
- 3
- RTECS
- LY4220000
- HS Code
- 29322090
Use
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
5 India supplier list of "Parthenolide"
- Product Name:Parthenolide,Tanacetumparthenium-CAS20554-84-1-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:512732 | Purity:Acell-permeablesesquiterpenelactonewithanti-inflammatory,antisecretory,andspasmo
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Parthenolide
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Parthenolide
- Company Type: Reagent
- Country/Region: INDIA
$0.00/ 25KG
- Product Name:Parthenolide
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA