Parthenolide manufacturers and suppliers in india

Parthenolide

Properties

Melting point:: 115-116 °C (lit.)

alpha: D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)

Boiling point:: 394.1±42.0 °C(Predicted)

Density: 1.13±0.1 g/cm3(Predicted)

storage temp.: -20°C

solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)

form: White solid

color: White

Merck: 14,7048

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

InChIKey: KTEXNACQROZXEV-PVLRGYAZSA-N

SMILES: O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|

LogP: 2.424 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H317

Precautionary statements: P280-P302+P352

Hazard Codes: Xi,C,F

Risk Statements: 11-34

Safety Statements: 22-24/25-45-36/37/39-26-16

WGK Germany: 3

RTECS: LY4220000

HS Code: 29322090

Use

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.