6-B-HYDROXY EPLERENONE

6-B-HYDROXY EPLERENONE Structure
CAS No.
209253-80-5
Chemical Name:
6-B-HYDROXY EPLERENONE
Synonyms
6β-Hydroxy Eplerenone;6--Hydroxy Eplerenone;6-B-HYDROXY EPLERENONE;Eplerenone Impurity 11;6-beta-Hydroxy Eplerenone;Eplerenone 6-β-Hydroxy Analog;Eplerenone 6-beta-Hydroxy Analog;(6β,7α,11α,17α)-9,11-Epoxy-6,17-dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-6,17-dihydroxy-3-oxo-, γ-lactone, methyl ester, (6β,7α,11α,17α)-;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-6,17-dihydroxy-3-oxo-, γ-lactone, methyl ester, (6β,7α,11α,17α)-
CBNumber:
CB0501022
Molecular Formula:
C24H30O7
Molecular Weight:
430.49
MOL File:
209253-80-5.mol
Modify Date:
2023/6/8 9:02:11

6-B-HYDROXY EPLERENONE Properties

Melting point 128-135°C
Boiling point 642.7±55.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
pka 13.16±0.70(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
NFPA 704
0
2 0

6-B-HYDROXY EPLERENONE Chemical Properties,Uses,Production

Description

6β-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.

Chemical Properties

White to Off-White Solid

Uses

6-B-HYDROXY EPLERENONE is a metabolite of Eplerenone, which is used alone or in combination with other medications to treat high blood pressure. 6-B-HYDROXY EPLERENONE is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

6-B-HYDROXY EPLERENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-B-HYDROXY EPLERENONE 6--Hydroxy Eplerenone (6β,7α,11α,17α)-9,11-Epoxy-6,17-dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester Eplerenone 6-beta-Hydroxy Analog 6-beta-Hydroxy Eplerenone Eplerenone Impurity 11 Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-6,17-dihydroxy-3-oxo-, γ-lactone, methyl ester, (6β,7α,11α,17α)- 6β-Hydroxy Eplerenone Eplerenone 6-β-Hydroxy Analog Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-6,17-dihydroxy-3-oxo-, γ-lactone, methyl ester, (6β,7α,11α,17α)- 209253-80-5 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids