Carprofen
- CAS No.
- 53716-49-7
- Chemical Name:
- Carprofen
- Synonyms
- c5720;imadyl;rimadyl;Ridamyl;Caroline;CARPROFEN;kanujofen;carprofeno;rac Carprofen;Carprofen CRS
- CBNumber:
- CB0663159
- Molecular Formula:
- C15H12ClNO2
- Molecular Weight:
- 273.71
- MOL File:
- 53716-49-7.mol
- Modify Date:
- 2024/5/31 17:33:32
| Melting point | 186-1880C |
|---|---|
| Boiling point | 509.1±35.0 °C(Predicted) |
| Density | 1.2011 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 4.84±0.30(Predicted) |
| color | white to beige |
| Merck | 14,1862 |
| InChI | InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19) |
| InChIKey | PUXBGTOOZJQSKH-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Cl)C=C2)C2=C1C=C(C(C)C(O)=O)C=C2 |
| CAS DataBase Reference | 53716-49-7(CAS DataBase Reference) |
| EPA Substance Registry System | 9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl- (53716-49-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-36-26 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FE3180000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 orally in mice: 400 mg/kg (Berger, Corraz) | |||||||||
| NFPA 704 |
|
Carprofen price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1713 | Carprofen ≥97% (HPLC) | 53716-49-7 | 10MG | ₹8302.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1713 | Carprofen ≥97% (HPLC) | 53716-49-7 | 50MG | ₹33438.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1452 | Carprofen Pharmaceutical Secondary Standard; Certified Reference Material | 53716-49-7 | 1G | ₹10857.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 33975 | Carprofen VETRANAL?, analytical standard | 53716-49-7 | 100MG | ₹11355.43 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2701 | Carprofen | 53716-49-7 | 1G | ₹10300 | 2022-05-26 | Buy |
Carprofen Chemical Properties,Uses,Production
Description
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis. Like many NSAIDs, carprofen inhibits both cyclooxygenases COX-1 and COX-2 (IC50s = 22.3 and 3.9 μM, respectively). It also inhibits fatty acid amide hydrolase (IC50 = 74 μM), blocking the metabolism of the cannabinoid receptor ligand, arachidonoyl ethanolamide .
Chemical Properties
Off-White Crystalline Solid
History
Carprofen has strong anti-inflammatory and analgesic activity. It has been used in human medicine for more than 10 years at doses of 150 to 600 mg per day. In human clinical trials, Carprofen was generally well tolerated. Most adverse reactions were transient and mild, such as gastrointestinal discomfort or pain and nausea. The incidence of side effects in humans is similar to that of aspirin and other NSAIDs. However, for commercial reasons, carprofen has been withdrawn from the market and is no longer available for human use.
Uses
Carprofen is a non steroidal anti-inflammatory that is used by veterinarians for the relief of arthritic systems in dogs. It can be used for joint pain or post operative inflammation. Carprofen, is al so used for the relief from pain and inflammation associated with osteoarthritis, hip dysplasia and other joint issues.
Definition
ChEBI: Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.
Mechanism of action
Carprofeng is a non-narcotic NSAID with analgesic and antipyretic properties. It acts in the same way as most NSAIDs in that Carprofeng acts by inhibiting cyclooxygenase (COX), which selectively inhibits COX-2, thereby inhibiting the release of several prostaglandins involved in the chronic inflammatory response that is thought to be present in canine OA.
Side effects
Common side effects of Carprofeng in dogs include vomiting, diarrhoea, loss of appetite, constipation, behavioural changes; and in severe cases, black stools, gastrointestinal ulcers and gastrointestinal haemorrhage, jaundice, skin changes, involuntary muscle movements, and kidney damage (increased thirst, increased urination, and refusal to eat).
Carprofen Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NGL Fine Chem limited | +91-8866366396 +91-8866366396 | Mumbai, India | 26 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Adani Wilmar Limited | +91-7383819375 +91-9099656790 | Gujarat, India | 34 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Alivira Animal Health Ltd | +91-8976959415 +91-9920774050 | Maharashtra, India | 35 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Zenfold Sustainable Technologies (ZST) | +91-9945888778 +91-9945888778 | Karnataka, India | 32 | 58 | Inquiry |
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 102 | 58 | Inquiry |
| Noven Lifesciences Private Limited | +91 40 23521246 | Andhra Pradesh, India | 21 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| NGL Fine Chem limited | 58 |
| Gonane Pharma | 58 |
| Chempifine Chemicals | 58 |
| Adani Wilmar Limited | 58 |
| Ralington Pharma | 58 |
| Alivira Animal Health Ltd | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Zenfold Sustainable Technologies (ZST) | 58 |
| Heer Pharma Pvt Ltd | 58 |
| Noven Lifesciences Private Limited | 58 |
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- Mar 8，2024
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