HERBIMYCIN A
- CAS No.
- 70563-58-5
- Chemical Name:
- HERBIMYCIN A
- Synonyms
- C11225;herbimycin;HERBIMYCIN A;(15r)-geldanamyci;antibiotictan420f;HerbiMycin, TAN 420F;HERBIMYCIN A USP/EP/BP;Herbimycin A, Streptomyces sp.;HERBIMYCIN A, STREPTOMYCES SPECIES;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS
- CBNumber:
- CB0756080
- Molecular Formula:
- C30H42N2O9
- Molecular Weight:
- 574.66
- MOL File:
- 70563-58-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 229-231 °C |
|---|---|
| Boiling point | 752℃ |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Flash point | >110°(230°F) |
| storage temp. | −20°C |
| solubility | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1. |
| pka | 8.56±0.70(Predicted) |
| form | powder |
| color | yellow |
| Sensitive | Light Sensitive & Hygroscopic |
| BRN | 4834067 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | LX8930000 |
| F | 10-21 |
| HS Code | 29419000 |
HERBIMYCIN A price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 70563-58-5 | 0.1MG | ₹32128.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 70563-58-5 | 1MG | ₹122344.15 | 2022-06-14 | Buy |
HERBIMYCIN A Chemical Properties,Uses,Production
Uses
Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.
Definition
ChEBI: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
General Description
A cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 μM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 μg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.
Biological Activity
Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.
HERBIMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | China | 25013 | 65 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| MedChemExpress | 021-58955995 | United States | 6398 | 58 | Inquiry |
| Creative Enzymes | 1-516-855-7709 | United States | 6057 | 58 | Inquiry |
| Shanghai kadel chemical technology co., LTD | 021-4007787-550 400-7787-550 | China | 10599 | 58 | Inquiry |