HERBIMYCIN A
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- ₹32128.6 - ₹122344.15
- Product name: HERBIMYCIN A
- CAS: 70563-58-5
- MF: C30H42N2O9
- MW: 574.66
- EINECS:
- MDL Number:MFCD00151702
- Synonyms:HERBIMYCIN A;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS;HERBIMYCIN A, STREPTOMYCES SPECIES;herbimycin A from streptomyces hygros-copicus;herbimycin A from streptomyces*hygroscopicus;Herbimycin A, Streptomyces sp.;C11225;[(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)-2,5,6,11-Tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl]carbamate
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 0.1MG
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product numberH6649
- Product descriptionHerbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
- Packaging0.1MG
- Price₹32128.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberH6649
- Product descriptionHerbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
- Packaging1MG
- Price₹122344.15
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 0.1MG | ₹32128.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 1MG | ₹122344.15 | 2022-06-14 | Buy |
Properties
Melting point :229-231 °C
Boiling point :752℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :−20°C
solubility :DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
pka :8.56±0.70(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive & Hygroscopic
BRN :4834067
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Boiling point :752℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :−20°C
solubility :DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
pka :8.56±0.70(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive & Hygroscopic
BRN :4834067
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.Related product price
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