Alsterpaullone
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- ₹16594.73 - ₹20270
- Product name: Alsterpaullone
- CAS: 237430-03-4
- MF: C16H11N3O3
- MW: 293.28
- EINECS:
- MDL Number:MFCD02683579
- Synonyms:ALSTERPAULLONE;9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5H)-ONE;9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5)-ONE;9-nitro-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one;9-Nitropaullone;NSC 705701;Alsterpaullone (9-Nitropaullone;ALSTERPAULLONE (9-NITROPAULLONE;NSC 705701)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product numberA4847
- Product descriptionAlsterpaullone ≥98% (HPLC), powder
- Packaging1MG
- Price₹16594.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number126870
- Product descriptionAlsterpaullone - CAS 237430-03-4 - Calbiochem A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC?? = 4 nM) and Cdk1/cyclin B (IC?? = 35 nM).
- Packaging1MG
- Price₹20270
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A4847 | Alsterpaullone ≥98% (HPLC), powder | 1MG | ₹16594.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 126870 | Alsterpaullone - CAS 237430-03-4 - Calbiochem A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC?? = 4 nM) and Cdk1/cyclin B (IC?? = 35 nM). | 1MG | ₹20270 | 2022-06-14 | Buy |
Properties
Melting point :>330℃
Boiling point :651.5±45.0 °C(Predicted)
Density :1.461±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :powder
pka :14.18±0.20(Predicted)
color :brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Boiling point :651.5±45.0 °C(Predicted)
Density :1.461±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :powder
pka :14.18±0.20(Predicted)
color :brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Alsterpaullone is a derivative of kenpaullone , an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Alsterpaullone has been used to inhibit the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.More related product prices
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