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(S)-CR8

(S)-CR8 Structure
  • ₹0
  • Product name: (S)-CR8
  • CAS: 1084893-56-0
  • MF: C24H29N7O
  • MW: 431.53
  • EINECS:
  • MDL Number:MFCD23160354
  • Synonyms:CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-;CR8, (S)-Isomer
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble,Ethanol: soluble
form :Off-white solid
pka :14.56±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

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Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Aladdin Scientific Shanghai SuperLan Chemcial Technique Centre Suzhou Chenrui Biotechnology Co. LTD Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. Riedel-de Haen AG ChemeGen(Shanghai) Biotechnology Co.,Ltd. Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.