INDIRUBIN-3'-MONOXIME
|
- ₹12059.05 - ₹54601.3
- Product name: INDIRUBIN-3'-MONOXIME
- CAS: 160807-49-8
- MF: C16H11N3O2
- MW: 277.28
- EINECS:
- MDL Number:MFCD02683594
- Synonyms:3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;INDIRUBIN-3’-MONOOXIME;Indirubin-3;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberI0404
- Product descriptionIndirubin-3′-oxime ≥98% (HPLC), solid
- Packaging1MG
- Price₹12059.05
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number402085
- Product descriptionIndirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem A potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC?? = 22 nM, 18
- Packaging1MG
- Price₹17860
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI0404
- Product descriptionIndirubin-3′-oxime ≥98% (HPLC), solid
- Packaging5MG
- Price₹54601.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I0404 | Indirubin-3′-oxime ≥98% (HPLC), solid | 1MG | ₹12059.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 402085 | Indirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem A potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC?? = 22 nM, 18 | 1MG | ₹17860 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I0404 | Indirubin-3′-oxime ≥98% (HPLC), solid | 5MG | ₹54601.3 | 2022-06-14 | Buy |
Properties
Melting point :247-249°C
Boiling point :532.2±50.0 °C(Predicted)
Density :1.50
storage temp. :room temp
solubility :DMSO: >10 mg/mL
form :solid
pka :8.66±0.20(Predicted)
color :Dark red or brown
Stability :Light Sensitive
CAS DataBase Reference :160807-49-8
Boiling point :532.2±50.0 °C(Predicted)
Density :1.50
storage temp. :room temp
solubility :DMSO: >10 mg/mL
form :solid
pka :8.66±0.20(Predicted)
color :Dark red or brown
Stability :Light Sensitive
CAS DataBase Reference :160807-49-8
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 μM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.More related product prices
Indirubin ALSTERPAULLONE KENPAULLONE (S)-CR8 RP107 BORRELIDIN Telatinib Apigenin PD 173074Related product price
- Indirubin
₹10600 - ALSTERPAULLONE
₹16594.73-20270 - KENPAULLONE
₹8800-48755.8
