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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >BORRELIDIN

BORRELIDIN

BORRELIDIN Structure
  • ₹65686.1
  • Product name: BORRELIDIN
  • CAS: 7184-60-3
  • MF: C28H43NO6
  • MW: 489.64
  • EINECS:
  • MDL Number:MFCD08276914
  • Synonyms:2-(7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL)-CYCLOPENTANECARBOXYLIC ACID;BORRELIDIN;BORRELIDINE;2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl)cyclopentane-1-carboxylic acid;Aids128115;Aids-128115;Cyclopentanecarboxylic acid, 2-(7-cyano-8, 16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4, 6-dien-2-yl)-;Quinquangulin K 031
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3061
  • Product descriptionBorrelidin from Streptomyces parvulus, ≥98% (HPLC)
  • Packaging1MG
  • Price₹65686.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) B3061 Borrelidin from Streptomyces parvulus, ≥98% (HPLC) 1MG ₹65686.1 2022-06-14 Buy

Properties

Melting point :143-145℃
Boiling point :584.45°C (rough estimate)
Density :1.1362 (rough estimate)
refractive index :1.6290 (estimate)
storage temp. :−20°C
solubility :DMSO: 1 mg/mL
form :White to off-white powder.
pka :4.56±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Borrelidin is a secondary metabolite produced by Streptomyces and other bacteria. It displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC50 = 0.8 nM) and inducing apoptosis in endothelial cells. Borrelidin also alters the splicing of VEGF mRNA, producing an antiangiogenic isoform of the growth factor. It has long been known as a powerful inhibitor of both eukaryotic and bacterial threonyl tRNA synthetase. Borrelidin is also an effective anti-malarial drug, as it kills P. falciparum with an IC50 value of 1.8 nM. At higher doses, it inhibits cyclin-dependent kinase in yeast (IC50 = 24 μM), resulting in growth arrest in the G1 phase.

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Suppliers and manufacturers

career henan chemical co
BORRELIDIN
₹1.00 /1KG
BORRELIDIN CAS:7184-60-3
CLEARSYNTH LABS LTD.
TargetMol Chemicals Inc.
Shaanxi Dideu Medichem Co. Ltd
BOC Sciences
Shanghai Acmec Biochemical Technology Co., Ltd.
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd RD International Technology Co., Limited TargetMol Chemicals Inc. Guangzhou Yaoguang Technology Co., Ltd.