Deserpidine
- CAS No.
- 131-01-1
- Chemical Name:
- Deserpidine
- Synonyms
- Harmonyl;Raunormine;Canescine;Reserpidine;Recanescine;DESERPIDINE;Reserpine Impurity 3;Deserpidine USP/EP/BP;Deserpidine Solution, 100ppm;methyl 17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
- CBNumber:
- CB0834483
- Molecular Formula:
- C32H38N2O8
- Molecular Weight:
- 578.65
- MOL File:
- 131-01-1.mol
- Modify Date:
- 2023/5/18 11:31:09
| Melting point | 228-232°; mp 230-232°; mp 138° and 226-232° with resolidification at 175° |
|---|---|
| alpha | D20 -163° (c = 0.5 in pyridine) |
| Boiling point | 638.28°C (rough estimate) |
| Density | 1.2277 (rough estimate) |
| refractive index | 1.6260 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 6.68 in 40% methanol |
| color | White to Off-White |
| CAS DataBase Reference | 131-01-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Deserpidine(131-01-1) |
Deserpidine Chemical Properties,Uses,Production
Chemical Properties
Crystalline solid; exists in three crystallineforms; mp 228–232°C (442.4–449.6°F); soluble in chloroform and methanol, insolublein water; pK 6.68 in saturated solution of40% methanol in water.
Uses
Deserpidine is found and extracted fromthe roots of Rauwolfia canescens L., andApocyanaceae. Therapeutically, it is used asan antihypertensive agent.
Health Hazard
The pharmacological properties of deserpi dine are similar to those of reserpine, causingsedation and tranquilization. Toxic effectsfrom high doses include drowsiness, depres sion, nausea, diarrhea, abdominal cramps,and hypotension. It is less toxic than reserpine. However, the poisoning effects may begreater than those of other Rauwolfia alka loids, such as rescinnamine. An oral LD50value in mice is 500 mg/kg.There is some evidence of its carcinogenic actions in animals and humans. Ratsgiven oral doses of 54 mg/kg over 77 weeksdeveloped blood tumor. In humans, it mayproduce tumors in skin and appendages.Cancer-causing properties of deserpidine,however, are not yet fully established.
Deserpidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8673 | 58 | Inquiry |
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