Febrifugine
- CAS No.
- 24159-07-7
- Chemical Name:
- Febrifugine
- Synonyms
- febrifugin;ferifugine;β-dichroine;Febrifugine;Radix Dichroae;(+)-Febrifugine;BETA-Febrifugine;Febrifugine USP/EP/BP;Febrifugine，Isofebrifugine;Febrifugine (6-Desoxyswietenine)
- CBNumber:
- CB11178705
- Molecular Formula:
- C16H19N3O3
- Molecular Weight:
- 301.34
- MOL File:
- 24159-07-7.mol
- Modify Date:
- 2024/7/2 8:54:59
| Melting point | 139-140°; mp 154-156° |
|---|---|
| alpha | D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol) |
| Density | 1.39 |
| storage temp. | 2-8°C |
| solubility | DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml |
| form | A crystalline solid |
| Boiling point | 508.2±60.0 °C(Predicted) |
| pka | 14.61±0.40(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 24159-07-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Toxicity | LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949) | |||||||||
| NFPA 704 |
|
Febrifugine Chemical Properties,Uses,Production
Description
Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.
Uses
Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.
Febrifugine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 118)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3772 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 23430 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | China | 2345 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
24159-07-7(Febrifugine)Related Search:
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Febrifugine
β-dichroine
3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one
Febrifugine，Isofebrifugine
3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone
BETA-Febrifugine
febrifugin
4(3H)-Quinazolinone, 3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-
Radix Dichroae
Febrifugine (6-Desoxyswietenine)
Febrifugine USP/EP/BP
ferifugine
(+)-Febrifugine
24159-07-7