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Halofuginone hydrobromide

Halofuginone hydrobromide Structure
CAS No.
64924-67-0
Chemical Name:
Halofuginone hydrobromide
Synonyms
STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide;Trans-halofuginone hydrobromide
CBNumber:
CB91230111
Molecular Formula:
C16H17BrClN3O3.HBr
Molecular Weight:
495.59
MOL File:
64924-67-0.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:40
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Halofuginone hydrobromide Properties

Melting point 247° (dec)
storage temp. Store at -20°C
solubility Soluble to 100 mM in DMSO.
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS09
Signal word  Danger
Hazard statements  H300+H310+H330-H315-H319-H410
Precautionary statements  P262-P273-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
RIDADR  UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany  3
RTECS  VA2397066

Halofuginone hydrobromide price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32481 Halofuginone hydrobromide VETRANAL?, analytical standard 64924-67-0 10MG ₹49405.3 2022-06-14 Buy
Sigma-Aldrich(India) 32481 Halofuginone hydrobromide VETRANAL?, analytical standard 64924-67-0 10MG ₹49405.3 2022-06-14 Buy
Product number Packaging Price Buy
32481 10MG ₹49405.3 Buy
32481 10MG ₹49405.3 Buy

Halofuginone hydrobromide Chemical Properties,Uses,Production

Description

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemical Properties

White to Off-White Solid

Uses

Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).

Definition

The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Biological Activity

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Toxicology

Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].

References

[1] Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, et al. “Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL?) for chickens for fattening and turkeys (Huvepharma N.V.).” EFSA Journal 20 12 (2022).

Halofuginone hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

Halofuginone hydrobromide Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Enki Biopharmaceuticals (Shanghai) Limited +86-0086-2157680326 +8613916707528 China 46 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +8618080483897 China 3424 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9326 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Amadis Chemical Company Limited 58
Enki Biopharmaceuticals (Shanghai) Limited 58
Chengdu Biopurify Phytochemicals Ltd. 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
Career Henan Chemica Co 58
AFINE CHEMICALS LIMITED 58
Baoji Guokang Bio-Technology Co., Ltd. 58

64924-67-0(Halofuginone hydrobromide)Related Search:

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Ru-19110 Tempostatin Unii-ptc2969mv1 rel-7-BroMo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone HydrobroMide trans-(+/-)-7-BroMo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone MonohydrobroMide 7-BroMo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobroMide HALOFUGINONEHYDROBROMIDE STENOROL 7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide 4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1), rel- (+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)- Trans-halofuginone hydrobromide HALOFUGINONE HBR ((2R,3S) AND (2S,3R) MIXTURE) 55837-20-2 (free) Halofuginone Hydrobromide 64924-67-0 (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide RU-19110(HBr) RU-19110 (hydrobromide) 7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide Haloperidone hydrobromide (3R,4R)-4-(2,5-Difluoro-phenyl)-3-methyl-4-[1,2,4]triazol-1-ylmethyl-oxetan-2-one 64924-67-0 C16H18Br2ClN3O3 Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals