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Halofuginone

Halofuginone Structure
CAS No.
55837-20-2
Chemical Name:
Halofuginone
Synonyms
HAL;aPKC[l];trans-l);empostatin;HALOFUGINONE;HALOQUGINONE;2Halofuginone;Halofuginone, >97%;Halofuginone USP/EP/BP;Halofuginone Hydrochloride
CBNumber:
CB0361552
Molecular Formula:
C16H17BrClN3O3
Molecular Weight:
414.68
MOL File:
55837-20-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:54:58
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Halofuginone Properties

Melting point >150°C dec.
Boiling point 595.8±60.0 °C(Predicted)
Density 1.73±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO : 9 mg/mL (21.70 mM)
form Solid
pka 14.61±0.40(Predicted)
color White to off-white
CAS DataBase Reference 55837-20-2(CAS DataBase Reference)

Halofuginone Chemical Properties,Uses,Production

Description

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemical Properties

Off-White Solid

Uses

Halofuginone is a halogenated derivative of febrigugine. It is Used as an antiprotozoal.

Biological Activity

Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga. It has antimalarial and anticoccidial actions. In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells. Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models. This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response. This prevents the differentiation of TH17 cells, blunting an autoimmune response.

Halofuginone Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 7-Bromo-6-chloro-4-quinazolinone

Preparation Products

Halofuginone Suppliers

Global( 252)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12458 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10318 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860 +86-18080483897 China 3424 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Hebei Mojin Biotechnology Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Shenzhen Nexconn Pharmatechs Ltd 58
Chengdu Biopurify Phytochemicals Ltd. 58

Halofuginone Spectrum

Halofuginone(55837-20-2)1HNMR

55837-20-2(Halofuginone)Related Search:

2-Quinolinol CHLOROPHOSPHONAZO III DROPERIDOL 2,2,6,6-Tetramethyl-4-piperidinol 1-Bromo-3-chloro-5,5-dimethylhydantoin
Triacetonediamine Cefoperazone Haloperidol Cefoperazone sodium +sulbactam sodium(1:1/2:1) Pipecuronium bromide
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Trazodone Difluorochloromethane Bromine Halofuginone hydrobromide
Halofuginone Lactate Diphenoxylate Halofuginone
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7-Bromo-6-chloro-3[3-(3-hydroxy-2-piperidi-nyl)-2-oxopropyl]-4(3H)-quinzolinone trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3h)-qui trans-l) 7-bromo-6-chloro-3-[3-[(2r,3s)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3h)-quinazolinone HALOFUGINONE 4(3h)-quinazolinone,7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropy 7-Bromo-6-chloro-3-(3-(3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one 7-Bromo-6-chlorofebrifugine Hydrochloride Halofuginone Hydrochloride rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrochloride HALOQUGINONE HAL aPKC[l] 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one Antifeverile Dichros Extract/Halofuginone 3-[2-Oxo-3-[(2S,3R)-3-hydroxy-2-piperidinyl]propyl]-6-chloro-7-bromo-4(3H)-quinazolinone 3-[2-Oxo-3-[(2R,3S)-3-hydroxy-2-piperidinyl]propyl]-6-chloro-7-bromo-4(3H)-quinazolinone empostatin 7-Bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone Halofuginone, >97% 7-bromo-6-chloro-3-[3-[(3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, rel- Halofuginone USP/EP/BP rel-7-Bromo-6-chloro-3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one 2Halofuginone 55837-20-2 C16H17BrClN3O3 C16H18BrCl2N3O3 C16H17BrClN3O3HBr Intermediates & Fine Chemicals Pharmaceuticals