dolasetron
- CAS No.
- 115956-12-2
- Chemical Name:
- dolasetron
- Synonyms
- Hsdb 7565;DOLASETRON;Dolasteron;Dorasetron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
- CBNumber:
- CB12130500
- Molecular Formula:
- C19H20N2O3
- Molecular Weight:
- 324.37
- MOL File:
- 115956-12-2.mol
- Modify Date:
- 2024/6/11 18:14:38
| Melting point | 278 ºC |
|---|---|
| Boiling point | 535.1±50.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 15.36±0.30(Predicted) |
| color | White |
| Water Solubility | Soluble |
| CAS DataBase Reference | 115956-12-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501 | |||||||||
| NFPA 704 |
|
dolasetron Chemical Properties,Uses,Production
Description
Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM). It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.
Chemical Properties
White Solid
Uses
Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
dolasetron Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8744 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5989 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9317 | 58 | Inquiry |
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