Dolasetron mesylate
- CAS No.
- 115956-13-3
- Chemical Name:
- Dolasetron mesylate
- Synonyms
- anzemet;mdl73147ef;Anzemet hydrate;DOLASETRON MESYLATE;Dalasetron (Mesylate);Dolasetron Mesylate USP;Dolasetron Mesylate hydrate;Dolasetron Mesylate (200 mg);DOLASETRON MESYLATE MONHYDATE;dolasetronmesylatemonohydrate
- CBNumber:
- CB8341693
- Molecular Formula:
- C20H26N2O7S
- Molecular Weight:
- 438.49
- MOL File:
- 115956-13-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 15:50:00
| Melting point | 278° |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: >30mg/mL |
| form | powder |
| color | white to off-white |
| CAS DataBase Reference | 115956-13-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
Dolasetron mesylate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D9571 | Dolasetron mesylate hydrate ≥98% (HPLC), powder | 115956-13-3 | 10MG | ₹9428.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D9571 | Dolasetron mesylate hydrate ≥98% (HPLC), powder | 115956-13-3 | 50MG | ₹38017.4 | 2022-06-14 | Buy |
Dolasetron mesylate Chemical Properties,Uses,Production
Description
Dolasetron was launched as Anzemet in Australia and the US for the prevention of nausea and vomiting in chemotherapy patients. It is a highly potent and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of compounds to be marketed for the treatment of chemotherapy-induced emesis. The last two approved in this class were Nazasetron (1994) and Ramosetron (1996). Anzemet was prepared by a seven step sequence from a cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10- 50 mg achieved major control of nausea and emesis in 73% of subjects and were well tolerated. Results from pharmacokinetic studies in humans showed that the clinical effects and duration of action seem to be due mainly to a major plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric alcohol obtained by enzymatic reduction of the cyclic ketone.
Uses
Dolasetron Mesylate acts as a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Dolasetron mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Swapnroop Drugs & Pharmaceuticals | 08048371984Ext 910 | Maharashtra, India | 20 | 58 | Inquiry |
| Jigs Chemicals | 09824076990 | Ahmedabad, India | 2 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LIMITED | +1 (866)- 901- 3784 | New Delhi, India | 31 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |