IWP-2
- CAS No.
- 686770-61-6
- Chemical Name:
- IWP-2
- Synonyms
- IWP 2;CS-803;IWP IWP;IWP-2;IWP 2;IWP-2-salt2;IWP 2, >=98%;IWP-2 USP/EP/BP;WNT INHIBITOR IWP-2;ABC 294640;ABC-294640;Wnt Antagonist II, IWP-2
- CBNumber:
- CB12518935
- Molecular Formula:
- C22H18N4O2S3
- Molecular Weight:
- 466.6
- MOL File:
- 686770-61-6.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 257 °C(dec.) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >5mg/mL |
| pka | 9.01±0.70(Predicted) |
| form | powder |
| color | Beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChIKey | WRKPZSMRWPJJDH-UHFFFAOYSA-N |
| CAS DataBase Reference | 686770-61-6 |
IWP-2 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I0536 | IWP-2 ≥98% (HPLC) | 686770-61-6 | 5MG | ₹15869.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I0536 | IWP-2 ≥98% (HPLC) | 686770-61-6 | 25MG | ₹62481.9 | 2022-06-14 | Buy |
| Sigma-Aldrich | 681671 | Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications. | 686770-61-6 | 10MG | ₹14260 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 681671 | Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primari | 686770-61-6 | 10MG | ₹14260 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.06072 | InSolution Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem A 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2) in DMSO. | 686770-61-6 | 5MG | ₹12940 | 2022-06-14 | Buy |
IWP-2 Chemical Properties,Uses,Production
Uses
IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
General Description
A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
Biochem/physiol Actions
IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts.
IWP-2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13184 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24607 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Hangzhou FandaChem Co.,Ltd. | 55 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
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