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Cyclopropyl carbinol

Cyclopropyl carbinol Structure
CAS No.
2516-33-8
Chemical Name:
Cyclopropyl carbinol
Synonyms
CYCLOPROPYLMETHANOL;CYCLOPROPANEMETHANOL;CPMO;CP-CARBINOL;(HYDROXYMETHYL)CYCLOPROPANE;CPC-OL;Cyclopropylmethane;RARECHEM AK ML 0580;CYCLOPROPYL CARBINOL;CYCLPOPROPANEMETHANOL
CBNumber:
CB1254806
Molecular Formula:
C4H8O
Molecular Weight:
72.11
MOL File:
2516-33-8.mol
Modify Date:
2023/12/26 11:30:52

Cyclopropyl carbinol Properties

Melting point -60 °C
Boiling point 123-124 °C738 mm Hg(lit.)
Density 0.89 g/mL at 25 °C(lit.)
refractive index n20/D 1.431(lit.)
Flash point 95 °F
storage temp. Flammables area
solubility Chloroform, Ethyl Acetate
pka 15.10±0.10(Predicted)
form Liquid
color Clear colorless
Specific Gravity 0.890
Water Solubility miscible
BRN 1846846
InChIKey GUDMZGLFZNLYEY-UHFFFAOYSA-N
CAS DataBase Reference 2516-33-8(CAS DataBase Reference)
NIST Chemistry Reference Cyclopropyl carbinol(2516-33-8)
EPA Substance Registry System Cyclopropanemethanol (2516-33-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H302-H319
Precautionary statements  P210-P301+P312+P330-P305+P351+P338
Hazard Codes  Xn,Xi,C,F
Risk Statements  10-22-36-34
Safety Statements  16-26-36-45-36/37/39
RIDADR  UN 1987 3/PG 3
WGK Germany  1
RTECS  GZ2212250
Hazard Note  Irritant
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29061990
NFPA 704
3
3 0

Cyclopropyl carbinol price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 482099 Cyclopropanemethanol ≥99.5% 2516-33-8 25ML ₹15728.73 2022-06-14 Buy
Sigma-Aldrich(India) 482099 Cyclopropanemethanol ≥99.5% 2516-33-8 250ML ₹25644.43 2022-06-14 Buy
Sigma-Aldrich(India) 482099 Cyclopropanemethanol ≥99.5% 2516-33-8 1L ₹52836.83 2022-06-14 Buy
TCI Chemicals (India) C0982 Cyclopropanemethanol min. 98.0 % 2516-33-8 5ML ₹1800 2022-05-26 Buy
TCI Chemicals (India) C0982 Cyclopropanemethanol min. 98.0 % 2516-33-8 25ML ₹5600 2022-05-26 Buy
Product number Packaging Price Buy
482099 25ML ₹15728.73 Buy
482099 250ML ₹25644.43 Buy
482099 1L ₹52836.83 Buy
C0982 5ML ₹1800 Buy
C0982 25ML ₹5600 Buy

Cyclopropyl carbinol Chemical Properties,Uses,Production

Chemical Properties

Clear colorless liquid

Uses

Cyclopropylmethanol used to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A, inhibitors against phosphodiesterase 3 (PDE3). Also used in the synthesis of benzodiazapin-2-ones

Preparation

The preparation of Cyclopropyl carbinol is as follows:A 1L three-necked flask was charged with 100 g (1mol) of methyl cyclopropanoate. 57g (1.5mol) of sodium borohydride, 500 mL of methanol, and then cooled to 2°C, 66.67g (0.5mol) of aluminum trichloride was added in batches and reacted overnight. The reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride, filtered, and the filtrate was concentrated and evaporated. The product was collected in a yield of 53.49g, a yield of 74.3%.

2516-33-8.png

General Description

Cyclopropanemethanol (Cyclopropyl carbinol, CPMO), a cycloalkanemethanol, is an anaesthetic. The coupling reaction of cyclopropanemethanol with alkynes to form substituted allylic alcohols has been reported. The microwave spectrum of CPMO has been recorded. Its rotational constants and dipole moment have been determined.

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