ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >ARRY-334543
ARRY-334543
- CAS No.
- 845272-21-1
- Chemical Name:
- ARRY-334543
- Synonyms
- CS-663;ASLAN001);Varlitinib;AR-00334543;ARRY-334543;Varlitinib Ditosylate;Varlitinib (ARRY-543);ARRY-334543 USP/EP/BP;ARRY-334543;ARRY334543;ARRY 334543 (Varlitinib)
- CBNumber:
- CB12582909
- Molecular Formula:
- C22H19ClN6O2S
- Molecular Weight:
- 466.94
- MOL File:
- 845272-21-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
| Boiling point | 637.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (107.08 mM; Need ultrasonic) |
| form | Powder |
| pka | 6.54±0.70(Predicted) |
| color | Off-white to yellow |
| CAS DataBase Reference | 845272-21-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H410-H302-H335 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
ARRY-334543 Chemical Properties,Uses,Production
Uses
ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.
Enzyme inhibitor
This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.
ARRY-334543 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 90)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | China | 9425 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | China | 39009 | 58 | Inquiry |
845272-21-1(ARRY-334543)Related Search:
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ARRY-334543
AR-00334543
Varlitinib
(R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline
(R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine
Varlitinib ARRY 334543
ARRY 334543 (Varlitinib)
N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-Quinazoline diamine
Varlitinib Ditosylate
(R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazolin
ASLAN001)
VARLITINIB (ARRY-334543; ASLAN001)
ARRY-334543;ARRY334543
Varlitinib (ARRY-543)
ARRY-334543;ARRY 334543;ARRY334543
CS-663
4,6-Quinazolinediamine, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-
ARRY-334543 USP/EP/BP
845272-21-1
C22H19ClN6O2S
Inhibitors