ChemicalBook > Product Catalog >API >Antineoplastic agents >Tinib Antineoplastic drugs >Lestaurtinib
Lestaurtinib
- CAS No.
- 111358-88-4
- Chemical Name:
- Lestaurtinib
- Synonyms
- SP 924;KT 5555;CEP 701;SPM-924;CS-1165;ritatinib; A 154475.0;lestaurtinib;KT-5555 hydrate;CEP-701 hydrate
- CBNumber:
- CB3506750
- Molecular Formula:
- C26H21N3O4
- Molecular Weight:
- 439.47
- MOL File:
- 111358-88-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Lestaurtinib price More Price(2)
Lestaurtinib Chemical Properties,Uses,Production
Chemical Properties
Lestaurtinib is Off-White Solid
Uses
Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Biological Activity
Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .
Lestaurtinib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 133)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 460 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| MSN LABORATORIES PRIVATE LTD | +91 40 30438600 | New Delhi, India | 230 | 58 | Inquiry |
| DR REDDYS LABORATORIES LTD | +91-40-49002900 | New Delhi, India | 201 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22854 | 58 | Inquiry |
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lestaurtinib
(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
SPM-924
CEP-701 hydrate
KT-5555 hydrate
Lestaurtinib hydrate
A 154475.0
(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
CEP 701
KT 5555
SP 924
Lestaurtinib
(KT-5555
CS-1165
(15S,16S,18R)-16-HYDROXY-16-(HYDROXYMETHYL)-15-METHYL-28-OXA-4,14,19-TRIAZAOCTACYCLO[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]OCTACOSA-1(26),2(6),7(27),8,10,12,20,22,24-NONAEN-3-ONE
LESTAURTINIB (CEP-701;KT-5555)
9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
KT5555-Lestaurtinib
Lestaurtinib USP/EP/BP
ritatinib
111358-88-4
C26H21N3O4
Inhibitor
Intermediates & Fine Chemicals
Pharmaceuticals