Lestaurtinib
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- ₹18380.85 - ₹73458.45
- Product name: Lestaurtinib
- CAS: 111358-88-4
- MF: C26H21N3O4
- MW: 439.47
- EINECS:
- MDL Number:MFCD09840836
- Synonyms:lestaurtinib;(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;SPM-924;CEP-701 hydrate;KT-5555 hydrate;Lestaurtinib hydrate; A 154475.0;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberC7869
- Product descriptionCEP-701 hydrate ≥98% (HPLC)
- Packaging1MG
- Price₹18380.85
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberC7869
- Product descriptionCEP-701 hydrate ≥98% (HPLC)
- Packaging5MG
- Price₹73458.45
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C7869 | CEP-701 hydrate ≥98% (HPLC) | 1MG | ₹18380.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7869 | CEP-701 hydrate ≥98% (HPLC) | 5MG | ₹73458.45 | 2022-06-14 | Buy |
Properties
Melting point :215-220°C
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
Boiling point :723.0±60.0 °C(Predicted)
Density :1.70±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :white powder
pka :13.37±0.40(Predicted)
color :White or off-white
Stability :Photosensitive
Safety Information
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative disorders. Lestaurtinib is a staurosporine analog that potently inhibits JAK2 kinase (IC50 = 1 nM) and downstream targets STAT5 (IC50 = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation. It has been used to reduce tumor growth in a xenograft model of pancreatic ductal adenocarcinoma, to inhibit cell growth in a trk-B overexpressing neuroblastoma xenograft model, and to block proliferation and induce apoptosis in Hodgkin lymphoma cell lines. Lestaurtinib has since been reported to potently inhibit the epigenetic kinase PRK1 in vitro (IC50 = 8.6 nM), inducing hypophosphorylation of histone H3 threonine 11 and blocking androgen-dependent gene expression in prostate cancer cells at a concentration of 5 μM.Related product price
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