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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Tinib Antineoplastic drugs >Erlotinib

Erlotinib

Erlotinib Structure
  • ₹0
  • Product name: Erlotinib
  • CAS: 183321-74-6
  • MF: C22H23N3O4
  • MW: 393.44
  • EINECS:689-196-2
  • MDL Number:MFCD02089651
  • Synonyms:ERLOTINIB;ERLOTINIB HCL SALT;4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline;n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine;Erlotinib Hydrochloirde;4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-;ERLOTININ;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :159-160 °C
Boiling point :553.6±50.0 °C(Predicted)
Density :1.24
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :5.32±0.30(Predicted)
color :White
CAS DataBase Reference :183321-74-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P331 Do NOT induce vomiting.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. The drug form of Erlotinib, Tarceva?, is used to treat certain forms of cancer, including non-small cell lung cancer.

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Suppliers and manufacturers

Jigs Chemical ltd Gonane Pharma Vivimed Labs Ltd Laurus Labs Ltd Sakar Healthcare Aspen Biopharma Labs Pvt Ltd Shreyaa Medilife Private Limited AKASH PHARMA EXPORTS A.J Chemicals CLEARSYNTH LABS LTD.