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KT5823

KT5823 Structure
CAS No.
126643-37-6
Chemical Name:
KT5823
Synonyms
KT5823;KT 5283;KT5823;KT-5823;PROTEIN KINASE INHIBITOR KT 5823;KT5823 - CAS 126643-37-6 - Calbiochem;9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7B-11A-triazadibenzo(A,G)cycloocta(cde)-trinden-1-one;(9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester;(9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9S,10R,12R)-
CBNumber:
CB7377637
Molecular Formula:
C29H25N3O5
Molecular Weight:
495.53
MOL File:
126643-37-6.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

KT5823 Properties

Boiling point 629.2±55.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility ethyl acetate: 5 mg/mL
form lyophilized powder
pka -1.01±0.60(Predicted)
color white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280-P271
Hazard Codes  Xi
WGK Germany  3
F  10
HS Code  29349990

KT5823 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 420321 KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). 126643-37-6 50μG ₹15469.99 2022-06-14 Buy
Sigma-Aldrich(India) K1388 KT 5823 ≥85% (HPLC), lyophilized powder 126643-37-6 100μG ₹25406.28 2022-06-14 Buy
Sigma-Aldrich(India) 420321 KT5823 - CAS 126643-37-6 - Calbiochem Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). 126643-37-6 100μG ₹23839.99 2022-06-14 Buy
Product number Packaging Price Buy
420321 50μG ₹15469.99 Buy
K1388 100μG ₹25406.28 Buy
420321 100μG ₹23839.99 Buy

KT5823 Chemical Properties,Uses,Production

Chemical Properties

Yellow powder

Uses

KT 5823 is a protein kinase inhibitor shown to increase TSH-induced NIS expression, and thus iodide uptake, in thyroid cells.

General Description

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 μM) and protein kinase A (Ki >10.0 μM) at higher concentrations.

Biological Activity

Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M. Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

KT5823 Preparation Products And Raw materials

Raw materials

K-252A

Preparation Products

KT5823 Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
bioleaper 18601717983 China 5615 58 Inquiry
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 China 25014 65 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9708 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 China 4550 62 Inquiry
Guangzhou Yaoguang Technology Co., Ltd. 13020159086 China 487 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
BOC Sciences 58
Aladdin Scientific 58
bioleaper 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
DC Chemicals 58
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Guangzhou Yaoguang Technology Co., Ltd. 58

126643-37-6(KT5823)Related Search:

ZM 336372 STO-609 (acetate) Sunitinib Malate GW5074 ANTI-ANDROGEN RECEPTOR
KT5823 (semi-synthetic derivative of K525a), Selective PKG Inhibitor, 0.4955kD KT5823 (Selective PKG Inhibitor) 11,12-Dihydroindolo[2,3-a]carbazole Lestaurtinib 9-CARBAZOLEPROPIONIC ACID
K-252C KT5823 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 9-ISOPROPYLCARBAZOLE K-252A
CARBAZOL-9-YL-METHANOL
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PROTEIN KINASE INHIBITOR KT 5823 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9S,10R,12R)- (9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester (9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))- 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R,10R,12R)- 9-Methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7B-11A-triazadibenzo(A,G)cycloocta(cde)-trinden-1-one KT 5283 KT5823;KT-5823 KT5823 KT5823 - CAS 126643-37-6 - Calbiochem 126643-37-6 C29H25N3O5 BioChemical Cell Biology Cell Signaling and Neuroscience Serine/Threonine Kinase Inhibitors Kinase/Phosphatase Biology Protein Kinase G (PKG) Cyclic Nucleotide related antibiotic Protein Kinase G (PKG)Cell Signaling and Neuroscience Enzyme Inhibitors by Enzyme Kinase/Phosphatase Biology P to Protein kinase CSerine/Threonine Kinase Biology Protein Kinase Inhibitors Serine/Threonine Kinase Inhibitors