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KPT-330

KPT-330 Structure
CAS No.
1393477-72-9
Chemical Name:
KPT-330
Synonyms
Selinexor;Xpovio;KPT-330;CS-1056;Aloradine;Selinexorb;KPT330; KPT 330;KPT330,Selinexor;KPT-330 USP/EP/BP;Selinexor (KPT-330)
CBNumber:
CB12681123
Molecular Formula:
C17H11F6N7O
Molecular Weight:
443.31
MOL File:
1393477-72-9.mol
Modify Date:
2024/1/23 15:27:11

KPT-330 Properties

Density 1.55±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
pka 9.74±0.43(Predicted)
form solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H332-H302-H312
Precautionary statements  P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501

KPT-330 Chemical Properties,Uses,Production

Uses

KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

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KPT-330 (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide Selinexor (KPT-330) (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)- Aloradine KPT330,Selinexor (KPT330)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide SELINEXOR;KPT330;KPT 330 KPT-330,Selinexor, >98% KPT330; KPT 330 CS-1056 (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide(Selinexor) Selinexor free base KPT-330 USP/EP/BP Selinexor Selinexor (KPT 330),Selinexor (KPT330) Avatrombopag Impurity 32 Hydrochloride Xpovio (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide Selinexorb 1393477-72-9 C17H11F6N7O Inhibitors API