2-Chlorophenol
- CAS No.
- 95-57-8
- Chemical Name:
- 2-Chlorophenol
- Synonyms
- ORTHO CHLORO PHENOL;O-CHLOROPHENOL;2-Chlorphenol;Phenol, 2-chloro-;2-chlorophenol(o-chlorophenol);orophenoL;septi-kleen;o-Chlorphenol;2-CHLOROPHENOL;2-chloro-pheno
- CBNumber:
- CB1325292
- Molecular Formula:
- C6H5ClO
- Molecular Weight:
- 128.56
- MOL File:
- 95-57-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/6 13:21:43
| Melting point | 8 °C (lit.) |
|---|---|
| Boiling point | 175-176 °C (lit.) |
| Density | 1.241 g/mL at 25 °C (lit.) |
| vapor pressure | 13.3 hPa (50 °C) |
| refractive index |
n |
| Flash point | 147 °F |
| storage temp. | under inert gas (Argon) |
| solubility | alcohol: freely soluble |
| pka | 8.49(at 25℃) |
| color | Clear Colourless to Pale Orange |
| Water Solubility | 28.5 g/L (20 ºC) |
| Merck | 14,2154 |
| BRN | 1905114 |
| Henry's Law Constant | 6.44 x 10-6 atm?m3/mol at 20 °C (Sheikheldin et al., 2001) |
| Dielectric constant | 8.2（19℃） |
| Stability | Stable. Hygroscopic. Combustible. Incompatible with oxidizing agents, acid anhydrides, acid chlorides. |
| InChIKey | ISPYQTSUDJAMAB-UHFFFAOYSA-N |
| LogP | 2.18 at 20℃ |
| CAS DataBase Reference | 95-57-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chlorophenol(95-57-8) |
| EPA Substance Registry System | o-Chlorophenol (95-57-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311+H331-H314-H411 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N,T,F | |||||||||
| Risk Statements | 20/21/22-51/53-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 28-61-28A-45-36/37-16-7 | |||||||||
| RIDADR | UN 2021 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SK2625000 | |||||||||
| F | 9 | |||||||||
| Autoignition Temperature | 550 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29081000 | |||||||||
| Hazardous Substances Data | 95-57-8(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 0.67 g/kg (Deichmann) | |||||||||
| NFPA 704 |
|
2-Chlorophenol price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C62794 | 2-Chlorophenol 98% | 95-57-8 | 100G | ₹3301.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C62794 | 2-Chlorophenol 98% | 95-57-8 | 1KG | ₹6733.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02253 | 2-Chlorophenol for synthesis | 95-57-8 | 100ML | ₹3450 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C62794 | 2-Chlorophenol 98% | 95-57-8 | 2KG | ₹13758.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02253 | 2-Chlorophenol for synthesis | 95-57-8 | 500ML | ₹4340 | 2022-06-14 | Buy |
2-Chlorophenol Chemical Properties,Uses,Production
Chemical Properties
2-Chlorophenol is a colourless to light brown liquid, All isomers have a characteristic odor. Slightly soluble in water, soluble in ethanol, ether and alkali solution. It is used to make dyes and other chemicals, and as a disinfectant, bactericide, and germicide.
Physical properties
Pale amber liquid with a slight phenolic, floral, or musty-type odor. At 40 °C, the average and lowest odor concentrations detected were 0.36 and 0.088 μg/L, respectively. At 25 °C, the average taste threshold concentration and the lowest concentration at which a taste was detected were 0.97 and 0.94 μg/L, respectively (Young et al., 1996).
Application
2-chlorophenol is used in medicine, pesticides, dyes and organic synthesis. It is an intermediate in the production of the pesticides Profenofos and Isoprocarb. It is also utilized in the manufacture of dye-stulfs and in the process for extracting sulphur and nitrogen compounds from coal. 2-chlorophenol functions as a reagent in the preparation of chlorophenyl phosphorodichloridothioate as potential synthon for oligonucleotide phosphorothioates.
Definition
ChEBI: 2-chlorophenol is a monochlorophenol and a 2-halophenol.
Preparation
2-chlorophenol is produced in 22% yields from the reaction of chlorine monoxide with phenol in carbon tetrachloride: 0.5 mole of tert-butyl hypochlorite is dropped, with stirring, into a solution or suspension of the 0.5 mole of phenol in 150-300 ml of carbon tetrachloride, the temperature being allowed to rise to the boiling point of the solvent. The mixture is then boiled under reflux for a further 2 hours, the carbon tetrachloride and the tert-butyl alcohol are distilled off, and the residue is fractionated collecting fraction boiling at 174.9 °C.
General Description
2-chlorophenol appears as a colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g / cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).
Air & Water Reactions
Very soluble in water
Reactivity Profile
2-Chlorophenol is a weak acid. Neutralizes bases in exothermic reactions. Incompatible with oxidizing agents. Incompatible with acid chlorides and acid anhydrides. Forms ethers, esters and salts with metals and amines .
Hazard
Toxic by skin absorption, inhalation, or ingestion. Strong irritant to tissue.
Health Hazard
Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Irritating to skin and eyes; direct contact may cause burns. Rats receiving lethal doses via oral, subcutaneous or intraperitoneal routes displayed similar symptoms: restlessness, increased breathing rate and motor weakness followed by tremors, chronic convulsions, dyspnea, coma and death.
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS and CHLORIDES.
Potential Exposure
Monochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.
Shipping
UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Pass 2-chlorophenol at least twice through a gas chromatography column. It has also been purified by fractional distillation. [Beilstein 6 IV 782.]
Incompatibilities
May form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.
Waste Disposal
Incinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.
2-Chlorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| PAARICHEM RESOURCES LLP | 58 |
| JSK Chemicals | 58 |
| Evans Fine Chem | 58 |
| CNS CHEMICALS | 58 |
| Dhara Industries | 58 |
| Aarti Industries Limited (AIL) | 58 |
| Super Hygienic Chemicals | 58 |
| CRD Industries | 58 |
| ARRAKIS INDUSTRIES LLP | 58 |
| Labort Fine Chem Pvt,. Ltd. | 58 |