3-Maleimidopropionic acid
- CAS No.
- 7423-55-4
- Chemical Name:
- 3-Maleimidopropionic acid
- Synonyms
- 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)PROPANOIC ACID;BMPA;3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID;MPA-OH;3-Maleimidopropionic;AKOS BC-0729;Mal-(CH2)2-COOH;n-maleoyl-β-alanine;MALEOYL-BETA-ALA-OH;RARECHEM AL CD 0912
- CBNumber:
- CB1371466
- Molecular Formula:
- C7H7NO4
- Molecular Weight:
- 169.13
- MOL File:
- 7423-55-4.mol
- Modify Date:
- 2023/10/20 9:49:57
| Melting point | 103-106 °C (lit.) |
|---|---|
| Boiling point | 382.5±25.0 °C(Predicted) |
| Density | 1.473±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.18±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in methanol, dimethyl formamide, alcohol and dimethyl sulfoxide. Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1528952 |
| InChIKey | IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 7423-55-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
3-Maleimidopropionic acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 250MG | ₹13690 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 1G | ₹33610 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M1962 | 3-Maleimidopropionic Acid min. 97.0 % | 7423-55-4 | 200MG | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1962 | 3-Maleimidopropionic Acid min. 97.0 % | 7423-55-4 | 1G | ₹9900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1962 | 3-Maleimidopropionic Acid min. 97.0 % | 7423-55-4 | 5G | ₹29500 | 2022-05-26 | Buy |
3-Maleimidopropionic acid Chemical Properties,Uses,Production
Chemical Properties
White to Pale Yellow Solid
Uses
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
Application
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.
General Description
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.
Synthesis
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.
3-Maleimidopropionic acid Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5929 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |