Hexetidine
- CAS No.
- 141-94-6
- Chemical Name:
- Hexetidine
- Synonyms
- Hexoral;Hextril;Triocil;Glypesin;Oraldene;Sterisil;NSC 17764;HEXETIDINE;Hexetidine CRS;RARECHEM AB PP 1426
- CBNumber:
- CB1442069
- Molecular Formula:
- C21H45N3
- Molecular Weight:
- 339.6
- MOL File:
- 141-94-6.mol
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 25°C |
|---|---|
| Boiling point | 160 °C/0.4 mmHg (lit.) |
| Density | 0.889 g/mL at 25 °C (lit.) |
| refractive index | 1.4649 |
| Flash point | 70°C |
| storage temp. | 2-8°C |
| solubility | acetone: soluble(lit.) |
| form | Liquid |
| pka | 8.3(at 25℃) |
| color | Clear Colourless |
| Water Solubility | Not miscible or difficult to mix in water. |
| Merck | 14,4703 |
| BRN | 161071 |
| InChIKey | DTOUUUZOYKYHEP-UHFFFAOYSA-N |
| LogP | 7.150 (est) |
| CAS DataBase Reference | 141-94-6(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl- (141-94-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P280-P304+P340+P312-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933599590 | |||||||||
| NFPA 704 |
|
Hexetidine price More Price(2)
Hexetidine Chemical Properties,Uses,Production
Chemical Properties
Hexetidine is a colorless or faint yellow-colored oily liquid with a characteristic amine odor.
Uses
Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.
Production Methods
Hexetidine is prepared by hydrogenation under pressure of 1,3- bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C using Raney nickel as a catalyst.
General Description
The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.
Hazard
Combustible.
Pharmaceutical Applications
Hexetidine is used as an antimicrobial preservative in cosmetics and nonparenteral pharmaceutical formulations. Therapeutically, hexetidine is mainly used as a 0.1% w/v solution in mouthwash formulations for the prevention and treatment of minor local infections, gingivitis, and mouth ulcers.
Safety
Hexetidine is mainly used in mouthwashes as a bactericidal and
fungicidal antiseptic. It is also used as an antimicrobial preservative
and is generally regarded as a relatively nontoxic and nonirritant
material at concentrations up to 0.1% w/v. Allergic contact
dermatitis and altered olfactory and taste perception have
occasionally been reported. Hexetidine is toxic when administered
intravenously.
Solutions of hexetidine in oil at concentrations of 5–10% w/v
cause strong primary irritations without sensitization in humans.
Long-term toxicological studies of up to 0.1% w/w of hexetidine in
food for 1 year do not show any toxic effect. Fetotoxicity,
embryotoxicity, and teratogenicity studies in rats of doses up to
50 mg/kg/day exhibit no sign of toxicity.
LD100 (cat, IV): 5–20 mg/kg
LD50 (dog, oral): 1.60 g/kg
LD50 (mouse, IP): 0.142 g/kg
LD50 (mouse, oral): 1.52 g/kg
LD50 (rat, oral): 0.61–1.43 g/kg
storage
Hexetidine is stable and should be stored in a well-closed container in a cool, dry place. Brass and copper equipment should not be used for the handling or storage of hexetidine.
Incompatibilities
Hexetidine is incompatible with strong oxidizing agents. Salts are formed with mineral and organic acids; strong acids cause opening of the hexahydropyrimidine ring, releasing formaldehyde.
Regulatory Status
Included in nonparenteral formulations licensed in Europe.
Hexetidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JD Chem India | +91-9899117932 +91-9555260045 | New Delhi, India | 41 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| JD Chem India | 91-9555260045 | Delhi, India | 38 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| Supplier | Advantage |
|---|---|
| JD Chem India | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| Alfa Aesar | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Pharma Affiliates | 58 |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 58 |
| JD Chem India | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
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