DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

CAS No.: 53016-31-2

Chemical Name:: DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

Synonyms: RWJ 10553;BRN 4202099;levonorgestreloxime;D-Norgestrel 3-oxime;(-)-NorelgestroMin-d6;Desacetylnorgestimate;17-Deacylnorgestimate;Levonorgestrel 3-oxime;17-Deacetylnorgestimate;Norelgestromin (1468454)

CBNumber:: CB1500552

Molecular Formula:: C21H29NO2

Molecular Weight:: 327.46

MOL File:: 53016-31-2.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:01

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DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Properties

Melting point	107-109°C
Boiling point	491.9±45.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMF: 11 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form	A solid
pka	12.22±0.60(Predicted)
color	White to off-white
CAS DataBase Reference	53016-31-2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H351-H360

Precautionary statements

P201-P308+P313

HS Code

2937230000

NFPA 704

	0
3		0

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Chemical Properties,Uses,Production

Description

Ortho Evra@ is the first birth control transdermal patch and contains a combination of norelgestromin and ethinylestradiol. The patch can be applied to the buttocks, lower abdomen, upper torso or arms; changed weekly for 3 weeks, followed by a patch-free week. Norelgestromin is the active metabolite produced following oral administration of norgestimate, the progestin component of the contraceptive, Ortho-Cyclen^?. The half-life value of norelgestromin was approximately 28 h. Following application, norelgestromin rapidly appeared in the serum, reached a plateau by approximately 48h and was maintained at an approximate steady state throughout the wear period. Hepatic metabolites of norelgestromin included norgestrel and various hydroxylated and conjugated metabolites that were eliminated by renal and fecal pathways. Ortho Evra produced ovarian suppression and cycle control. It was significantly more effective in suppressing follicular development than the leading oral contraceptive Triphasil^? (ethinyl estradiol/levomorgestrel); was as effective in preventing pregnancies and had similar tolerability profile. The patch offers 99% efficacy when used appropriately, as shown by three clinical trials. However, a statistically significantly greater proportion of pregnancies occurred among women weighing 90 kg or more. Ortho Evra^? was well tolerated, with 2.6% of women discontinuing treatment due to mild to moderate reactions at the site of application. Thus, the patch combined the efficacy of oral contraceptives with the convenience of just once-weekly dosing.

Chemical Properties

White Solid

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Preparation Products And Raw materials

Raw materials

Preparation Products

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Suppliers

Global( 57)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	China	4128	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Jiangxi Jianglan Pure Biological Reagent Co., Ltd.	021-54720761	CHINA	6136	58	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry
GADOR SA	(5411) 4858-9000	Argentina	12	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
TargetMol Chemicals Inc.	58
Nanjing Doge Biomedical Technology Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Jiangxi Jianglan Pure Biological Reagent Co., Ltd.	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	58
GADOR SA	58

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Norgestrel DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

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(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one OxiMe (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one-d6 OxiMe (-)-NorelgestroMin-d6 (17alpha)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime (E)- and (Z)-17-Deacetylnorgestimate mixture Norgestimate metabolite Norelgestromin 17-Desacetyl Norgestimate ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Deacetylnorgestimate (Mixture of (E)- And (Z)-17-Deacetyl Norgestimate) (17R)-13-Ethyl-17-hydroxy-18,19-dinor-pregna-4-ene-20-yne-3-oneoxime [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregna-4-ene-20-yne-3-oneoxime Desacetylnorgestimate DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) ,10-alpha,13-alpha,14-beta)- 18,19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,oxime,(8-alpha,9-beta levonorgestreloxime 17-Deacetylnorgestimate (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Oxime 18-Methylnorethindrone oxime BRN 4202099 D-Norgestrel 3-oxime Levonorgestrel 3-oxime RWJ 10553 13-ETHYL-17_-HYDROXY-18,19-DINORPREGN-4-EN-20-YN-3-ONE OXIME 17-Desacetyl Norgestimate Solution, 100ppm 17-Desacetyl Norgestimate (Mixture of Isomers) 17-Deacylnorgestimate 17-Desacetyl Norgestimate-d7 (Mixture ofIsomers) (Norelgestromin-d7) 17-Desacetyl Norgestimate (Mixture of Isomers) (Norelgestromin) 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, oxime, (17α)- (E/Z)-17-Deacetylnorgestimate 17-Desacetyl NorgestimateQ: What is 17-Desacetyl Norgestimate Q: What is the CAS Number of 17-Desacetyl Norgestimate Q: What is the storage condition of 17-Desacetyl Norgestimate Q: What are the applications of 17-Desacetyl Norgestimate Norelgestromin (1468454) Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) (1471958) Deacetylnorgestimate (Mixture of (E)- And (Z)) Drug Metabolite,inhibit,Inhibitor,Norgestimate metabolite Norelgestromin Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) (8R,9S,10R,13S,14S,17R,E)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime Deacetylnorgestimate (25 mg) ((E)- and (Z)-17-deacetyl norgestimate mixture) (PLANNED TO BE DISCONTINUED) Norgestimate metabolite Norelgestromin (mixture of isomers) 53016-31-2 Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids