ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Contraceptives >Norgestimate
Norgestimate
- CAS No.
- 35189-28-7
- Chemical Name:
- Norgestimate
- Synonyms
- D-138;orf10131;Norgestimat;NORGESTIMATE;Norgestimate CRS;NorgestimateUsp27;dexnorgestrelacetime;Norgestimate (200 mg);Norgestimate USP/EP/BP;Norgestimate (1471914)
- CBNumber:
- CB2110884
- Molecular Formula:
- C23H31NO3
- Molecular Weight:
- 369.5
- MOL File:
- 35189-28-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/7 17:33:14
| Melting point | 216°C |
|---|---|
| alpha | D25 +110° |
| Boiling point | 497.9±45.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble5mg/mL (clear solution) |
| form | powder |
| pka | 12.21±0.60(Predicted) |
| color | white to beige |
| optical activity | [α]/D 43±3°, c = 1 in chloroform |
| BRN | 6440219 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 35189-28-7 |
| EPA Substance Registry System | 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17.alpha.)- (35189-28-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H361fd | |||||||||
| Precautionary statements | P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63-22-36/38-62 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JF7976000 | |||||||||
| HS Code | 2937230000 | |||||||||
| NFPA 704 |
|
Norgestimate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2119 | Norgestimate Pharmaceutical Secondary Standard; Certified Reference Material | 35189-28-7 | 500MG | ₹21812.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 94497 | Norgestimate analytical standard | 35189-28-7 | 50MG | ₹9038.88 | 2022-06-14 | Buy |
Norgestimate Chemical Properties,Uses,Production
Description
Norgestimate is an orally-effective progestogen, recently launched in combination with ethinyl estradiol as an oral contraceptive.
Chemical Properties
White Crystalline Solid
General Description
Norgestimate, (17α)-17-acetyloxy-13-ethyl-18,19-dinor-pregn-4-en-20yn-3-one oxime, is a 19-nortestosterone, 3-oxime prodrug that is orally active andused with an estrogen in oral contraceptive products. It hasminimal androgenic action. Norgestimate is metabolized to17-deacetylnorgestimate (norelgestromin) and norgestrel,which provide the progestational action.
Metabolism
Norgestimate is considered to be a pro-proges tin (prodrug), because it rapidly undergoes a two-s tep m etabolic transformation to form two active products, norelgestromine (levonorgestrel 3-oxime) and levonorgestrel. Deacetylation occurs in the intestine and liver, whereas convers ion of the 3-oxime to the corresponding ketone occurs primarily in the liver. Unlike the other progestins mentioned, norgestimate and its metabolites are not bound to SHBG.
Norgestimate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 156)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| LUPIN LTD | +91 124 4885000 / +91 124 3325000 | New Delhi, India | 191 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
35189-28-7(Norgestimate)Related Search:
13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl acetate
(17R)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
Norgestimate (200 mg)
(17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-OxiMe
(17a)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-Oxime
D-138
(17-alpha)-17-(acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one3-oxime
18,19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha
19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha)-1
d-13-beta-ethyl-17-alpha-ethynyl-17-beta-acetoxygon-4-en-3-oneoxime
dexnorgestrelacetime
orf10131
NORGESTIMATE
Norgestimat
NORGESTIMATE, USP STANDARD
NorgestimateUsp27
acetic acid [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] ester
Norgestimate for system suitability CRS
Norgestimate CRS
Norgestimate (Mixture of Z and E Isomers)
18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17α)-
(8R,9S,10R,12R,14S,17S)-12-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
Norgestimate USP/EP/BP
NorgestimateQ: What is
Norgestimate Q: What is the CAS Number of
Norgestimate Q: What is the storage condition of
Norgestimate Q: What are the applications of
Norgestimate
35189-28-7 Norgestimate
Norgestimate (1471914)
4-ESTREN-17α- ETHYNYL-18-HOMO-17β- OL-3-ONE(-)-ACETATE-OXIME
(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
35189-28-7
25189-28-7
C23H31NO3
Metabolite Reference Standard
Isotopically Labeled Pharmaceutical Reference Standard
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